Evidence supporting the use of: Vitamin D (cholecalciferol)
For the health condition: Calcium Deficiency

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin D (cholecalciferol) is scientifically validated for use in the support and treatment of calcium deficiency. Vitamin D plays a crucial physiological role in calcium homeostasis and bone metabolism. It facilitates the intestinal absorption of calcium by increasing the expression of calcium-binding proteins in the gut epithelium. Without adequate vitamin D, only a small fraction of dietary calcium is absorbed, leading to hypocalcemia, secondary hyperparathyroidism, and the risk of bone demineralization disorders such as rickets in children and osteomalacia in adults (Holick, NEJM, 2007).

Multiple randomized controlled trials and meta-analyses have demonstrated that vitamin D supplementation increases serum calcium concentrations and improves bone mineral density, especially in populations at risk of deficiency (elderly, people with limited sun exposure, malabsorption syndromes). Clinical guidelines from authorities such as the Endocrine Society and the National Institutes of Health recommend vitamin D supplementation as a standard adjunct to calcium therapy in the prevention and treatment of calcium deficiency and related bone disorders.

Therefore, the use of cholecalciferol to support or treat calcium deficiency is strongly supported by robust scientific evidence, with well-documented mechanisms and clinical benefit.

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