Evidence supporting the use of: Pomegranate
For the health condition: Cancer (natural therapy for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pomegranate (Punica granatum) has been used traditionally in various cultures for its health-promoting properties, but its potential role in cancer prevention and therapy has garnered scientific interest in recent years. Laboratory studies have demonstrated that pomegranate extracts, particularly from the fruit's juice, peel, and seeds, contain bioactive compounds such as punicalagins, ellagic acid, and anthocyanins. These compounds exhibit antioxidant, anti-inflammatory, and antiproliferative effects in cell cultures and animal models of cancer, including prostate, breast, colon, and lung cancers.

Some in vitro and animal studies have shown that pomegranate extract can inhibit cancer cell growth, induce apoptosis (programmed cell death), and reduce tumor angiogenesis (formation of new blood vessels that feed tumors). For example, in prostate cancer models, pomegranate juice and extract have been shown to slow tumor progression. Limited human studies exist; a few small clinical trials in prostate cancer patients have suggested that pomegranate juice may slow the rise of PSA (prostate-specific antigen) levels, but these studies lacked rigorous controls and had small sample sizes.

While the preclinical evidence is promising, robust clinical trials in humans are lacking, and there is insufficient evidence to recommend pomegranate as a standalone or primary therapy for cancer. It may be considered as a complementary approach, but patients should always consult with healthcare providers. Thus, scientific support exists, but is currently weak to moderate (rated 2/5) due to the lack of large, well-controlled human studies.

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Other ingredients used for Cancer (natural therapy for)

7-hydroxymatairesinol (HMR)
acai berry
ajoene
aloe vera
amino acids
green chiretta
anthocyanins
apricot
arabinogalactan
ashwagandha
astaxanthin
astragalus
barberry
basil
beet
berberine
berry flavor
beta and delta tocopherols
beta caryophyllene
beta-pinene
Beta-Glucan
beta-sitosterol
bisabolol
black cohosh
black cumin
black garlic
sesame
black walnut
blackberry
blueberry
Indian frankincense
branched-chain amino acids
broccoli
bromelain
bupleurum falcatum
burdock
cannabis sativa oil
capsaicinoids
carrot
cat's claw
catechins
caterpillar mushroom
chaga mushroom
chamomile
champignon
Chinese salvia root
chlorella
chrysin
cinnamon
citrus oil
citrus pectin
clove
coconut milk
cordyceps
cowage seed
cryptoxanthin
turmeric
curcumin
cuspidatum root
d-glucarate
dandelion
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DIM (diindolylmethane)
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
flavonols
flaxseed
gamma tocopherol
garlic bulb
genistein
genistin
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
greek mountain tea
onion
green tea
hemp oil
hesperetin
hesperidin
hibiscus
HMR lignan
Indian tinospora
indole-3-carbinol
knotweed
jujube
kale
kelp
lactoferrin
lentinula edodes mycelia
lignans
lion's mane
liquid liver fractions
luteolin
lychee
lycopene
maitake mushroom
mangosteen
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
mixed carotenoids
moringa
mustard seed
naringin
nettle
oleanolic acid
olive
omega-3 fatty acids
oyster mushroom
papain
parsley
pectin
perilla
phellodendron amurense
phenolic acids
phytocannabinoids
phytosterols
plantain
plum fruit
pomegranate
pomelo
protein
butyric acid
pumpkin
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
rutin
scrophularia root
secoisolariciresinol diglucoside
selenium
shiitake mushroom
black ginger
soybean
sphaeranthus indicus
spirulina
sulforaphane glucosinolate
tocotrienols
tomato
trans-pterostilbene
tributyrin
triphala
turkey tail mushroom
Urolithin A
vitamin A
vitamin B
vitamin C
vitamin D
vitamin D3
seaweed
wasabia japonica
wheat grass
whey protein
mulberry
zinc
sarsaparilla
red clover
yellow root
suma
jiaogulan
typhonium
xanthium (cockleburs)
gastrodia
atractylodes
papaya
shen-chu
mugwort
neem tree
nut grass
alpinia galangal
clerodendrum indicum
commiphora
smilax
tinospora cordifolia
caesalpinia crista
rubia cordifolia
bee pollen
lingzhi
buckthorn
pau d'arco
morus
lemongrass
myrrh
root tuber
ferulic acid
siler root
cistanche
dioscorea
dodder
ganoderma
hyacinth bean
morinda
trichosanthes
zanthoxylum
royal jelly
polyphenols
purslane
coix
polyporus
aster root
noni
biota seed
nopal
goji berry
paw paw
millet seed
herbal blend (proprietary)
algae
indigo leaves
cocoa
AMP-activated protein kinase (AMPK)
cayenne pepper
soy isoflavones
ashitaba
soursop
15,16-Dihydrotanshinone I
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-Hydroxyandrostenedione
7,4-Dimethoxyflavone
Arugula
Agarikon Mushroom
akebia
Antler
Alpha-Humulene
Amethoflavone
Amygdalin
Ankaflavin
Angelica
Apigenin
Aronia melanocarpa
Allicin
Antrodia camphorata
Achyranthes
Auricularia
Anamu
Abrus
Albizia
Artesunate
AHCC
Ajuga
Andrographolide
Avocado
Amentoflavone
Acetogenin
Acacetin
Allophycocyanin
Alpha-Lipoic Acid
Astragaloside
Armillaria mellea
anthocyanidins
Andrographis
Adzuki bean
Ampelopsin
Agrimonia pilosa
Asteracea
Allyl Sulfide
Acemannan
allyl isothiocyanate
Alkylglycerols
Alliin
Arabinoxylan
Allium tuberosum
Alantolactone
Anti-aromatase
Arctiin
Arjunolic acid
Artepillin C
Astragalin
Atractylone
Bee Propolis
Black Seed
Baikal Skullcap
Bai Ji
Baphicacanthus cusia
Bidens pilosa
Broussonetia
bergenin
Beta-hydroxybutyrate
Betulinic acid
Brassica
Boswellic Acid
Butea monosperma
Black galingale
Beef liver
Barleria
Berberis (unspecified)
Bitter Grass
Bok Choy
Baicalein
Beta-lapachone
Bee hive
Bael
Bloodroot
biochanin
Butternut
Basidiomycota
Betanin
Bauhinia
Boswellia
Baccharoides anthelmintica
Banyan
Butein
Bioflavonoids
Barbasco
Bee products
Black Nightshade
Bombax
Borassus aethiopum
Bacteria
benzyl isothiocyanate
Baicalin
Bignay
Boerhavia diffusa
Caffeic Acid
Cumin
Chinese Silkvine
Curry leaf
Caryophyllene
Cinnamomum
Chinese Mountain Ant
Cyanobacteria
Calotropis gigantea
Condurango
Calycosin
Chlorophyllin
Cod Liver Oil
Coriolus mushroom
Cactus
Carvacrol
Cynomorium
Capillary Artemisia
Cyanidin
chlorogenic acid
Chinese Fleeceflower
Curcuminoid
Capsaicin
Chinese Pond Turtle
Cancerina
Cereal grass
Chinese Raisintree
Cowherb
Cruciferous
Casticin
Curcumen
Centella asiatica
Cinnamic Acid
Curcuma
Carnosol
Chalcone
C-Phycocyanin
Chaparral
Cabbage
Chirata
Crinum latifolium
Cherimoya
Cephalotaxus sinensis
Chebulinic acid
Cinnamaldehyde
Corilagin
Coumaric acid
Crocetin
Cynaropicrin
Cytokines
Costus
Celastrus
Celosia
Carnosic acid
Cannabichromene
Cannabigerol
Dunaliella salina
Docosahexaenoic Acid
Diallyl sulfide
Delphinidin
Decursin
Daidzein
Diosgenin
Didymin
Diterpenes
Dithiolthiones
Diosmetin
epicatechin
Ellagic Acid
Eupolyphaga sinensis
Eclipta
Elk antler
Emblicanin
Eicosapentaenoic Acid
Euphorbia
Embelia
Ellagitannin
Emodin
Enokitake
Fig
Fiber
Flavonoids
Flavonones
Flammulina velutipes
Garlic
Galangal
Isoflavones
Lotus
Little ironweed
Mistletoe
Periwinkle
Rhubarb
Soy Protein
Sumac
walnut

Products containing pomegranate

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Metagenics AdvaClear
Metagenics AdvaClear
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Metagenics CardioLux® HDL
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change Daily Essentials
Designs For Health H-S-N Radiance™
Thorne Hormone Advantage DIM Advantage
Vitabase Life's Essentials Plus
Douglas Laboratories Methlyated Resveratrol Plus
Thorne Ovarian Care
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health PaleoReds®
Designs For Health PhytoBiome™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse Plus™ 570g
Pure Encapsulations Poly-Prebiotic Powder
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Pomegranate Plus
Designs For Health Prostect™
Pure Encapsulations PureLean® Protein
Pure Encapsulations SP Ultimate
Pure Encapsulations SP Ultimate
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories Ultra Preventive® X
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations Vascular Relax
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Pure Encapsulations Women's Nutrients
Pure Encapsulations XanthiTrim