Evidence supporting the use of: Pomegranate
For the health condition: Cancer (natural therapy for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pomegranate (Punica granatum) has been used traditionally in various cultures for its health-promoting properties, but its potential role in cancer prevention and therapy has garnered scientific interest in recent years. Laboratory studies have demonstrated that pomegranate extracts, particularly from the fruit's juice, peel, and seeds, contain bioactive compounds such as punicalagins, ellagic acid, and anthocyanins. These compounds exhibit antioxidant, anti-inflammatory, and antiproliferative effects in cell cultures and animal models of cancer, including prostate, breast, colon, and lung cancers.

Some in vitro and animal studies have shown that pomegranate extract can inhibit cancer cell growth, induce apoptosis (programmed cell death), and reduce tumor angiogenesis (formation of new blood vessels that feed tumors). For example, in prostate cancer models, pomegranate juice and extract have been shown to slow tumor progression. Limited human studies exist; a few small clinical trials in prostate cancer patients have suggested that pomegranate juice may slow the rise of PSA (prostate-specific antigen) levels, but these studies lacked rigorous controls and had small sample sizes.

While the preclinical evidence is promising, robust clinical trials in humans are lacking, and there is insufficient evidence to recommend pomegranate as a standalone or primary therapy for cancer. It may be considered as a complementary approach, but patients should always consult with healthcare providers. Thus, scientific support exists, but is currently weak to moderate (rated 2/5) due to the lack of large, well-controlled human studies.

More about pomegranate
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Other ingredients used for Cancer (natural therapy for)

15,16-Dihydrotanshinone I
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7,4-Dimethoxyflavone
7-hydroxymatairesinol (HMR)
Abrus
Acacetin
Acai berry
Acemannan
Acetogenin
Achyranthes
Adzuki bean
Agarikon Mushroom
Agrimonia pilosa
AHCC
Ajoene
Ajuga
Akebia
Alantolactone
Albizia
Algae
Alkylglycerols
Allicin
Alliin
Allium tuberosum
Allophycocyanin
Allyl isothiocyanate
Allyl sulfide
Aloe vera
alpha-humulene
alpha-lipoic acid
alpinia galangal
amentoflavone
amethoflavone
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
amygdalin
anamu
Andrographis
andrographolide
Angelica
ankaflavin
anthocyanidins
anthocyanins
anti-aromatase
antler
Antrodia camphorata
apigenin
apricot
arabinogalactan
arabinoxylan
arctiin
Arjunolic acid
Armillaria mellea
Aronia melanocarpa
Artepillin C
artesunate
arugula
ashitaba
ashwagandha
astaxanthin
aster root
Asteraceae
astragalin
astragaloside
astragalus
atractylodes
atractylone
Auricularia
avocado
Baccharoides anthelmintica
bacteria
bael
bai ji
baicalein
baicalin
Baikal Skullcap
banyan
Baphicacanthus cusia
barbasco
barberry
Barleria
Basidiomycota
basil
Bauhinia
bee hive
bee pollen
bee products
bee propolis
Beef liver
beet
benzyl isothiocyanate
berberine
Berberis (unspecified)
bergenin
beta and delta tocopherols
beta caryophyllene
beta-glucan
beta-hydroxybutyrate
beta-lapachone
beta-pinene
beta-sitosterol
betanin
betulinic acid
Bidens pilosa
bignay
biochanin
bioflavonoids
biota seed
bitter grass
black cohosh
black cumin
black galingale
black garlic
black ginger
black nightshade
black seed
black walnut
blackberry
bloodroot
blueberry
Boerhavia diffusa
bok choy
Bombax
Borassus aethiopum
Boswellia
Boswellic Acid
branched-chain amino acids
Brassica
broccoli
bromelain
Broussonetia
buckthorn
bupleurum falcatum
burdock
Butea monosperma
butein
butternut
butyric acid
C-phycocyanin
cabbage
cactus
Caesalpinia crista
caffeic Acid
Calotropis gigantea
calycosin
cancerina
cannabichromene
cannabigerol
Cannabis sativa oil
capillary artemisia
capsaicin
capsaicinoids
carnosic acid
carnosol
carrot
carvacrol
caryophyllene
casticin
cat's claw
catechins
caterpillar mushroom
cayenne pepper
Celastrus
Celosia
Centella asiatica
Cephalotaxus sinensis
cereal grass
chaga mushroom
chalcone
chamomile
champignon
chaparral
chebulinic acid
cherimoya
Chinese fleeceflower
Chinese mountain ant
Chinese pond turtle
Chinese raisintree
Chinese salvia root
Chinese silkvine
chirata
chlorella
chlorogenic acid
chlorophyllin
chrysin
cinnamaldehyde
cinnamic acid
Cinnamomum
cinnamon
cistanche
citrus pectin
Clerodendrum indicum
clove
cocoa
coconut milk
cod liver oil
coix
commiphora
condurango
cordyceps
corilagin
coriolus mushroom
costus
coumaric acid
cowage seed
cowherb
Crinum latifolium
crocetin
cruciferous
cryptoxanthin
cumin
Curcuma
curcumen
curcumin
Curcuminoid
curry leaf
cuspidatum root
cyanidin
cyanobacteria
cynaropicrin
Cynomorium
cytokines
d-glucarate
daidzein
dandelion
decursin
delphinidin
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl sulfide
diallyl trisulfide (DATS)
didymin
DIM (diindolylmethane)
dioscorea
diosgenin
diosmetin
diterpenes
dithiolthiones
docosahexaenoic Acid
dodder
DPA (docosapentaenoic acid)
Dunaliella salina
Eclipta
eicosapentaenoic acid
eleuthero
elk antler
ellagic acid
ellagitannin
Embelia
emblicanin
emodin
enokitake
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
Euphorbia
Eupolyphaga sinensis
eurycomanone
evodiamine
farnesol
fatty acids
ferulic acid
fiber
fig
fisetin
fish oil
Flammulina velutipes
flavanols
flavanones
flavans
flavones
flavonoids
flavonolignan
flavonols
flavonones
flaxseed
Flueggea suffruticosa
fo-ti
Fomes fomentarius
formononetin
fruit
fucoidan
fucosterol
fucoxanthin
fungus
Gac
Galangal
galangin
Gallesia
gallic acid
gamma tocopherol
ganoderma
garcinol
Garcinone A
Garcinone B
Garcinone C
Garcinone D
Garcinone E
garden cress
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garlic bulb
gastrodia
genistein
genistin
geraniol
geranylgeraniol
Gigartina
ginger
ginkgetin
ginkgo biloba
ginseng
Ginsenosides
Glabridin
Glucan peptides
Glucoraphanin
Glucosinolates
Glutamine
goji berry
gooseberry
gotu kola
Graviola
Greek mountain tea
green chiretta
green tea
Guava
Gypenoside
Haematococcus pluvialis
heal-all
Hedyotis
Helicteres isora
Hematoporphyrin
hemp
hemp oil
Herb Robert
herbal blend (proprietary)
hericium mushroom
hesperetin
hesperidin
hibiscus
HMR lignan
Honokiol
Huang hua
hyacinth bean
hydroxytyrosol
Hygrophila
Hypericin
Hyperoside
Hyphomycetes
hypsizygus marmoreus
icariin
Ilex
Indian coraltree
Indian fagonia
Indian frankincense
Indian sarsparilla
Indian tinospora
indigo leaves
indole
indole-3-carbinol
iridoids
Isatis
Isoalantolactone
isodon excisus
isodon rubescens
isoflavones
isoliquiritigenin
isoquinoline alkaloids
isosilybin
isothiocyanates
isovitexin
Jaboticaba
Java brucea
jiaogulan
Job\'s tears
jujube
Kaempferol
kale
Kefir
kelp
knotweed
Kokilaksha
Kombucha
Kutkins
labrador tea
lactalbumin
Lactoferrin
Laggera pterodonta
Laminaria
Lapachol
Lebbek
Legume protein
lemongrass
Lentinan
Lentinula edodes mycelia
Leptadenia
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Ligusticum
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limonene
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limonoid
linalool
lingzhi
lion's mane
liquid liver fractions
little ironweed
lodhtree
long pepper
loquat
Loranthus
lotus
luffa
lupulone
luteolin
lychee
Lycium
lycopene
Lycoris
Maclura tricuspidata
madder
magnolol
maitake mushroom
mangiferin
mangosteen
mangostene xanthone
mangostin
marigold
Marine lipid
Marine protein
Maslinic acid
Matapalo Tree
Matcha
Mate
Mayapple
Maytenus ilicifolia
medium chain triglycerides (MCT)
Melatonin
Mesima
Methoxylated flavones
Methylselenocysteine
millet seed
Millettia
Mistletoe
mixed carotenoids
Momordica
Momordicosides
Mondo grass
Monoterpenes
Morinda
Moringa
Morus
Mugwort
Mulberry
Mushroom
mustard seed
Myricetin
Myrosinase
Myrrh
Naphthoquinones
Nardostachys
Naringenin
Naringin
Neem tree
Neoandrographolides
Neoxanthin
Nettle
Nigella seed
Nimbidin
Nobiletin
Nomilin
noni
nopal
nut grass
Oldenlandia diffusa
oleanolic acid
Oleuropein
olive
omega-3 fatty acids
onion
Onosma bracteatum
Oroxylum indicum
Osthole
Oxymatrine
Oxystelma
oyster mushroom
paeoniflorin
pagoda tree
Pansit-pansitan
Pao Pereira
papain
papaya
Paris polyphylla
parsley
parthenolide
Patrinia
pau d'arco
paw paw
Pentacyclic triterpenoids
perilla
Periwinkle
Persimmon
Petiveria
Phaeophyceae
Phellodendron
phellodendron amurense
Phenethyl isothiocyanate (PEITC)
phenolic compounds
Phenylpropanoids
phlorotannins
Phycocyanin
Phyllanthus
Physalis angulata
phytocannabinoids
Phytoestrogens
phytosterols
Piceid
Piper nigrum
Piper retrofractum
Piperine
Plantago
plantain
Plectranthus amboinicus
Pleurotus eryngii
Pluchea
plum fruit
Podophyllum
Pokeweed
Polydatin
Polygonatum
Polygonum
polymethoxylated flavones
polyphenols
polyporous mushroom
Polyporus
polysaccharides
pomegranate
pomelo
Portulaca
proanthocyanidins
Propolis
protein
Prunus
Puerain
Puerarin
pumpkin
punicalagins
punicalin
punicosides
purslane
Pyrrosia
quercetin
red clover
reishi mushroom
resin
resveratrol
Rhabdosia rubescens
rhizome
rhubarb
root tuber
Rosa roxburghii
rosemary
rosmarinic acid
royal jelly
Rubia cordifolia
Rubia yunnanensis
Rubiaceae
rutin
S-allylcysteine
Sagebrush
Salidroside
Salmon Oil
Salvianolic acid
Sanguisorba
Sapogenin
saponins
Sargassum
sarsaparilla
Schisandrins
Schizophyllum commune
Scoparia dulcis
Scopoletin
scrophularia root
seaweed
secoisolariciresinol diglucoside
Selaginella
selenium
Semecarpus anacardium
sesame
Sesamin
Sesbania
Sesquiterpenes
Sete sangrias
shen-chu
shiitake mushroom
Shikonin
Shilajit
Shogaol
Sichuan Lovage
Sicklepod
siler root
Silkmoth
Silybin
Simaruba
Sinensetin
Sinigrin
Smartweed
smilax
Solanaceae
Solanum anguivi
Solanum indicum
Sophora
soursop
Soy
soy isoflavones
Soy Protein
soybean
Spanish Needle
Sphaeranthus indicus
spirulina
Stereospermum
Stilbenoid
Sulfated polysaccharide
Sulforaphane
sulforaphane glucosinolate
suma
Sumac
Sweet Annie
Sword Bean
Syringic acid
Tamarind
Tangeretin
Tanshinone
Taraxasterol
Taxifolin
Tea
Terminalia
Terpenoids
Tetracyclic oxindole alkaloids
Theabrownin
Theaflavin
Thiosulfinate
Thistle
Thuja
Thymoquinone
Thymus
Tinospora cordifolia
tocotrienols
Trametes
Trans-pterostilbene
Tremella
tributyrin
Trichosanthes
Triphala
Triterpenes
Tulbaghia
Tumerone
Turkey tail mushroom
turmeric
Turmerones
Tylophorine
typhonium
Typhonium flagelliforme
Uncaria
Urolithin A
Ursolic Acid
Varuna
Verbascoside
Vestitol
Vicenin
Vine tea
Viniferin
Violet
Viscum coloratum
vitamin A
vitamin B
vitamin C
vitamin D
vitamin D3
Vitexicarpin
Vitexin
Walnut
Wasabi
wheat grass
Whey protein
White Tea
Winter Begonia
Winter Savory
Withanolides
Wogonin
Wulinshen
xanthium (cockleburs)
Xanthohumol
Xanthone
Xanthoparmelia
Xanthophyll
Xanthorrhizol
Xylaria nigripes
Yacon
Yellow root
Yew
Yumberry
zanthoxylum
Zedoary
Zinc
Zingerone
Zingiberene

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