Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits, vegetables, and grains, and has been studied for its potential anti-cancer properties. The scientific interest in quercetin for cancer therapy is primarily based on laboratory (in vitro) and animal (in vivo) studies. These studies suggest that quercetin can inhibit the growth of various cancer cell lines, induce apoptosis (programmed cell death), and reduce inflammation—all processes relevant to cancer development and progression. Mechanistically, quercetin appears to modulate signaling pathways involved in cell proliferation, such as PI3K/Akt, MAPK, and NF-κB. Additionally, its antioxidant properties may contribute to its potential protective effects against cancer. However, despite promising preclinical data, robust evidence from well-designed human clinical trials is lacking. Most clinical studies have been small, preliminary, or focused on quercetin as part of a combination therapy rather than as a sole agent. There is insufficient clinical evidence to recommend quercetin as a primary or adjunctive treatment for cancer. Major health authorities and cancer organizations do not currently endorse quercetin as a cancer therapy. In summary, while there is some scientific rationale for the use of quercetin in cancer based on preclinical research, the evidence from human studies is weak and inconclusive, meriting a low evidence rating. Individuals should consult healthcare professionals before using quercetin for cancer support, as it should not replace conventional treatments.

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