Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) has garnered scientific interest as a potential adjunct in cancer prevention and therapy, largely due to its role in cell differentiation, immune modulation, and regulation of cell proliferation and apoptosis. Epidemiological studies have observed that populations with higher serum vitamin D levels tend to have lower incidences of certain cancers, particularly colorectal, breast, and prostate cancers. Laboratory studies demonstrate that vitamin D3 and its active metabolite, calcitriol, can inhibit proliferation and induce apoptosis in cancer cells in vitro and in animal models.

However, clinical evidence supporting vitamin D3 supplementation as a cancer treatment or preventive agent remains inconclusive. Randomized controlled trials (RCTs) have produced mixed results. Some meta-analyses suggest a modest reduction in cancer mortality (but not incidence) with vitamin D supplementation, while others find no significant benefit. Notably, most studies focus on prevention rather than direct treatment of established cancers, and there is no consensus on optimal dosing or patient populations who might benefit most.

Current guidelines do not recommend vitamin D3 as a sole or primary therapy for cancer, but maintaining adequate vitamin D status is encouraged for general health and may support conventional cancer treatments. Thus, while there is scientific rationale and some supporting evidence, it is not robust enough to justify vitamin D3 as a standalone natural therapy for cancer.

More about vitamin D3
More about Cancer (natural therapy for)

Other ingredients used for Cancer (natural therapy for)

Other health conditions supported by vitamin D3

Products containing vitamin D3

Designs For Health Acnutrol™ capsules
Designs For Health ADK-Evail™
Metagenics AdvaClear
Metagenics AdvaClear
Thorne Advanced Bone Support Oscap
Thorne Advanced Nutrients Multivitamin
Metagenics Akkermansia Co.™ Healthy Weight with Glucose Control
Metagenics Axis Endo™ Mango
Pure Encapsulations Balanced Immune
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Designs For Health BioFizz® Immune
Metagenics Bone Builder Active
Metagenics Bone Builder Chewable Chocolate
Metagenics Bone Builder Plus
Metagenics Bone Builder Forte
Metagenics Bone Builder Magnesium
Metagenics Bone Builder Prime
Metagenics Bone Builder with Magnesium
Douglas Laboratories C-D-Zinc
Pure Encapsulations Cal/Mag/D
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations Calcium K/D
Designs For Health Calcium Malate
Pure Encapsulations Calcium with Vitamin D3
Designs For Health Chromium Synergy™
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change Daily Essentials
Integrative Therapeutics Clinical Nutrients HP
Pure Encapsulations Cortisol Calm
Pure Encapsulations Cortisol Calm
Designs For Health D Evail™ 10K
Designs For Health D-Evail™ Supreme
Pure Encapsulations Daily Immune
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health Emulsi-D3 Synergy™
Pure Encapsulations EmulsiSorb K2D3
Pure Encapsulations Energize Plus™ Pure Pack
Metagenics Fem Prenatal®
Metagenics GI Sustain™ Powder
Designs For Health Hi-Po Emulsi-D3™
Metagenics ImmuCore
Metagenics Immune Defense Pack
Integrative Therapeutics ITI Vitamin D3 5000 iu
Integrative Therapeutics K-PAX MitoNutrients
Douglas Laboratories K2-D3 with Astaxanthin
Metagenics Ketogenic Shake Chocolate
Metagenics Ketogenic Shake Vanilla
Klean Athlete Klean-D 1000
Klean Athlete Klean-D ™ 5000 IU
Klean Athlete Klean Essential Aminos + HMB®
Klean Athlete Klean Multivitamin ™
Designs For Health Liposomal Cat's Claw
Designs For Health Liposomal D Supreme
Douglas Laboratories Liquid Cal/Mag/D
Integrative Therapeutics Liquid Calcium Magnesium Berry Flavored
Integrative Therapeutics Liquid Calcium Magnesium Orange Vanilla
Douglas Laboratories Liquid D and K
Douglas Laboratories Liquid Multivitamin
Douglas Laboratories Liquid Vitamin D-3
Integrative Therapeutics Magtein L-Threonate Plus
Thorne MediClear Plus
Thorne Men's Multi 50+
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaGlycemX™
Metagenics MetaGlycemX
Metagenics MetaKids Multi Soft Chew Grape
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Metagenics MetaKids Vitamin D3 Liquid
Douglas Laboratories Methlyated Resveratrol Plus
Pure Encapsulations Multi t/d
Pure Encapsulations Multi t/d
Metagenics Multigenics®
Metagenics Multigenics Chewable Orange
Metagenics Multigenics Intensive Care
Metagenics Multigenics Intensive Care without Iron
Metagenics Multigenics without Iron
Douglas Laboratories Muscle Protect™ with HMB®
Designs For Health MyoStim™
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950® A without Copper & Iron
Pure Encapsulations Nutrient 950® with NAC
Pure Encapsulations Nutrient 950® with Vitamin K
Pure Encapsulations Nutrient 950® without Copper, Iron & Iodine
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Pure Encapsulations OsteoBalance
Pure Encapsulations OsteoBalance
Designs For Health Osteoben®
Designs For Health OsteoForce™
Designs For Health OsteoForce™
Designs For Health OsteoForce™ Supreme
Integrative Therapeutics Osteoprime Forte
Integrative Therapeutics Osteoprime Ultra
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse
Designs For Health Plant Protein Cleanse Plus™ 570g
Metagenics PlusOne® Daily Prenatal Packs
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Designs For Health Prostate Supreme™
Designs For Health Prostate Supreme™
Integrative Therapeutics ProThrivers Multivitamin
Pure Encapsulations PureDefense with NAC
Pure Encapsulations PureDefense with NAC
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureHeart® K2D
Pure Encapsulations PureLean® Protein
Pure Encapsulations PurePals with Iron
Pure Encapsulations PureResponse™ Multivitamin
Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Pure Encapsulations Sereniten Plus
Douglas Laboratories Sereniten Plus
Pure Encapsulations SP Ultimate
Pure Encapsulations SP Ultimate
Pure Encapsulations Synergy K
Pure Encapsulations Synergy K
Integrative Therapeutics Testosterone Formula
Metagenics Testralin®
Pure Encapsulations Thyroid Support Complex
Metagenics Thyrosol
Designs For Health Twice Daily Essential Packets
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Metagenics Ultra Glucose Control® Chocolate
Metagenics Ultra Glucose Control Chocolate
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Glucose Control Vanilla
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ® 2 Daily
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Metagenics Ultra Prostagen Concentrated
Douglas Laboratories Ultra Protein Green
Pure Encapsulations Ultra Pure Pack
Metagenics UltraClear Detox Powder
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations VisionPro Nutrients
Thorne Vitamin D-1,000
Douglas Laboratories Vitamin D 1,000 I.U.
Thorne Vitamin D-10,000
Vitabase Vitamin D-3
Douglas Laboratories Vitamin D 5,000 I.U.
Douglas Laboratories Vitamin D 5,000 I.U.
Thorne Vitamin D-5000 NSF
Thorne Vitamin D + K2
Thorne Vitamin D Liquid
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Synergy
Pure Encapsulations Vitamin D3
Pure Encapsulations Vitamin D3 10 mcg 400 IU
Metagenics Vitamin D3 1000™
Vitabase Vitamin D3 1000 IU
Metagenics Vitamin D3 10,000 + K
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Metagenics Vitamin D3 2000 Complex
Integrative Therapeutics Vitamin D3 2000 iu
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 250 mcg 10,000 IU
Pure Encapsulations Vitamin D3 250 mcg 10,000 IU
Metagenics Vitamin D3 5000
Metagenics Vitamin D3 5000 + K
Metagenics Vitamin D3 Liquid
Pure Encapsulations Vitamin D3 Vegan
Pure Encapsulations Vitamin D3 Vegan
Pure Encapsulations Vitamin D3 VESIsorb®
Integrative Therapeutics Vitamin K2+D3
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets