Relationship: Cancer (prevention) and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Cancer (prevention)

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Source of validity: Scientific
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DHA (Docosahexaenoic Acid) and Cancer Prevention: Scientific Evidence Overview

DHA, an omega-3 polyunsaturated fatty acid found abundantly in fish oil, has garnered interest for its potential role in cancer prevention and support. The rationale for its use is primarily supported by scientific investigation, though the evidence is still emerging and not yet definitive.

Mechanistically, DHA is believed to exert anti-cancer effects through several pathways, including the modulation of cell membrane composition, reduction of inflammation, induction of apoptosis (programmed cell death) in malignant cells, and inhibition of angiogenesis (formation of new blood vessels that feed tumors). Additionally, DHA may reduce the production of certain eicosanoids and cytokines that promote tumor growth.

Preclinical studies (animal and cell culture models) have provided robust evidence that DHA can inhibit the growth of various cancer cells, including breast, colon, and prostate cancers. However, when translating these findings to humans, the clinical evidence remains limited and somewhat inconsistent. Some observational studies suggest a correlation between higher dietary intake of DHA (or fish consumption) and reduced cancer risk, particularly for colorectal and breast cancers. Nonetheless, randomized controlled trials (RCTs) in humans have not consistently demonstrated a significant preventive effect.

Overall, the scientific evidence supporting DHA for cancer prevention is promising but preliminary. More large-scale, well-designed human trials are needed to establish definitive recommendations. As such, DHA is not yet a standard therapy for cancer prevention, but may be considered as a supportive dietary component within the context of a balanced diet.

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15,16-Dihydrotanshinone I
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
7-hydroxymatairesinol (HMR)
8-Bromo-7-Methoxychrysin
Abalone
Acacetin
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Acetogenin
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alpinia galangal
amentoflavone
American Pawpaw
amethoflavone
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ampelopsin
amygdalin
anamu
Andrographis
andrographolide
ankaflavin
anthocyanidins
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anthocyanosides
anti-aromatase
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apigenin
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apricot
arabinoxylan
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Artepillin C
arugula
ashitaba
ashwagandha
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aster root
Asteraceae
astragalin
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rosmarinic acid
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S-allylcysteine
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Salvianolic acid
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seaweed
secoisolariciresinol diglucoside
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soybean
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spirulina
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sulforaphane glucosinolate
suma
Sword Bean
Syringic acid
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tocotrienols
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tributyrin
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turmeric
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typhonium
Typhonium flagelliforme
Uncaria
Urolithin A
Ursolic Acid
vegetable and fruit blend (proprietary)
Vegetable Protein
Verbascoside
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Vicenin
Vine tea
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vitamin A
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vitamin C
vitamin D
vitamin D3
Vitexin
Wakame
Walnut
Wasabi
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Watercress
Wax Gourd
wheat germ
wheat grass
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Xanthoparmelia
Xanthophyll
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Xylaria nigripes
Yacon
Yellow root
Yerba mate
Yumberry
Yuzu
zanthoxylum
Zedoary
Zinc
Zingerone
Zingiberene
Zucchini

Products containing DHA (docosahexaenoic acid)

Health Concerns

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Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

DHA (Docosahexaenoic Acid) and Cancer Prevention: Scientific Evidence Overview

Other ingredients used for Cancer (prevention)

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaenoic acid)For the health condition: Cancer (prevention)

Table of Contents

Synopsis

DHA (Docosahexaenoic Acid) and Cancer Prevention: Scientific Evidence Overview

Other ingredients used for Cancer (prevention)

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Cancer (prevention)