Relationship: Cancer (prevention) and EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Cancer (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid found primarily in marine oils, has been extensively researched for its potential role in cancer prevention and support. The scientific basis for EPA’s use in this context stems from its anti-inflammatory properties and its influence on cell membrane structure, signaling pathways, and gene expression. Chronic inflammation is a known risk factor for cancer development, and EPA’s ability to reduce inflammatory mediators (such as prostaglandin E2) is a proposed mechanism for its protective effects.

Preclinical studies demonstrate that EPA can inhibit cancer cell proliferation, induce apoptosis, and suppress angiogenesis in various cancer models. Epidemiological research suggests that populations with higher intakes of omega-3 fatty acids, including EPA, tend to have lower incidences of certain cancers, such as colorectal and breast cancer. However, clinical trials in humans have produced mixed results. Some randomized controlled trials and meta-analyses report modest reductions in cancer risk or improvements in outcomes, while others show no significant benefit.

Overall, while there is a plausible scientific rationale and some supportive data, the evidence is not robust or consistent enough to unequivocally endorse EPA supplementation solely for cancer prevention. Most guidelines do not currently recommend omega-3 supplementation as a standard preventive strategy for cancer, but EPA may still be considered as part of a healthy diet with multiple benefits. Further large-scale, well-designed clinical trials are needed to clarify its role.

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Acemannan
Acetogenin
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Adzuki bean
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alpinia galangal
amentoflavone
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amethoflavone
AMP-activated protein kinase (AMPK)
ampelopsin
amygdalin
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anthocyanidins
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anthocyanosides
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Antrodia camphorata
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apricot
arabinoxylan
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astragalin
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Products containing EPA (eicosapentaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: EPA (eicosapentaenoic acid)For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Cancer (prevention)