Relationship: Cancer (prevention) and selenium

Evidence supporting the use of: Selenium
For the health condition: Cancer (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Selenium is an essential trace mineral with antioxidant properties, and its potential role in cancer prevention has been extensively studied. Early observational studies and laboratory experiments suggested that selenium might protect against cancer due to its ability to reduce oxidative DNA damage and influence immune function. This led to significant interest and large-scale clinical trials, such as the Nutritional Prevention of Cancer (NPC) trial and the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Some early findings, particularly from the NPC trial, indicated a possible reduction in certain cancer risks (notably prostate, colorectal, and lung cancer) in populations with low baseline selenium status.

However, subsequent and more rigorous randomized controlled trials, including SELECT, failed to demonstrate a significant protective effect of selenium supplementation for cancer prevention in the general population. Some studies even suggested potential risks with high-dose supplementation, including possible increased risks for type 2 diabetes and other adverse effects.

Current scientific consensus, as reflected in guidelines from organizations such as the American Cancer Society and the National Cancer Institute, states that there is insufficient evidence to recommend selenium supplementation for cancer prevention in individuals with adequate selenium status. Selenium remains an essential nutrient, but supplementation beyond dietary needs is not supported for cancer prevention based on current evidence.

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Products containing selenium

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Evidence supporting the use of: Selenium
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by selenium

Products containing selenium

Health Concerns

Brands

Evidence supporting the use of: SeleniumFor the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by selenium

Products containing selenium

Evidence supporting the use of: Selenium
For the health condition: Cancer (prevention)