Relationship: Cancer (prevention) and vitamin A

Evidence supporting the use of: Vitamin A
For the health condition: Cancer (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A and its derivatives (retinoids) have been investigated for their potential role in cancer prevention and treatment. The scientific rationale stems from vitamin A's involvement in regulating cell differentiation, proliferation, and apoptosis—processes that, when dysregulated, contribute to carcinogenesis. Preclinical studies and some epidemiological research suggest that adequate vitamin A intake may lower the risk of certain cancers, particularly epithelial cancers such as those of the lung, skin, and cervix. Synthetic retinoids have also been used therapeutically; for example, all-trans retinoic acid (ATRA) is an established treatment for acute promyelocytic leukemia (APL), demonstrating substantial efficacy. However, large randomized controlled trials in the general population have produced mixed or negative results. Notably, the Beta-Carotene and Retinol Efficacy Trial (CARET) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) found that high-dose supplementation with vitamin A or beta-carotene did not prevent cancer and, in some groups (such as smokers), actually increased lung cancer risk. As a result, routine supplementation with vitamin A for cancer prevention is not recommended and may be harmful in certain populations. The current scientific consensus is that while vitamin A is essential for overall health and deficiency should be avoided, there is insufficient evidence to support vitamin A supplementation as a strategy for cancer prevention in the general population.

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Other ingredients used for Cancer (prevention)

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acai berry
ajoene
akkermansia muciniphila
algal oil
alpha-carotene
alpha-linolenic acid (ALA)
anthocyanins
apple
apricot
ashwagandha
astaxanthin
astragalus
barberry
barley
basil
beet
berberine
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beta and delta tocopherols
beta caryophyllene
beta-carotene
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beta-sitosterol
bisabolol
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black garlic
radish
sesame
black tea
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blueberry
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brussel sprouts
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capsaicinoids
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chia seed
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chlorella
chlorophyll
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diallyl disulfide (DADS)
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Products containing vitamin A

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Evidence supporting the use of: Vitamin A
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by vitamin A

Products containing vitamin A

Health Concerns

Brands

Evidence supporting the use of: Vitamin AFor the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by vitamin A

Products containing vitamin A

Evidence supporting the use of: Vitamin A
For the health condition: Cancer (prevention)