Relationship: Cancer (prevention) and vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Cancer (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) has been investigated for its potential role in cancer prevention and treatment, with a particular focus on its regulation of cell growth, apoptosis, and immune function. Epidemiological studies suggest that populations with higher serum vitamin D levels tend to have lower incidences of certain cancers, notably colorectal, breast, and prostate cancers. Mechanistically, vitamin D receptors are present in many tissues, and activation of these receptors can inhibit cancer cell proliferation and angiogenesis while promoting cell differentiation and apoptosis.

However, while observational studies and preclinical research offer promising associations, randomized controlled trials (RCTs) in humans have produced mixed results. Some RCTs suggest a modest reduction in cancer risk with vitamin D supplementation, but others find negligible or no effect. For example, a 2019 meta-analysis of RCTs indicated a slight reduction in cancer mortality but not in cancer incidence with vitamin D supplementation.

Currently, most expert guidelines do not recommend vitamin D3 supplementation solely for cancer prevention or treatment, except in individuals with deficiency. The overall evidence is considered limited and not conclusive enough to warrant routine use for cancer. Thus, while there is some scientific basis for its potential role, the strength of evidence is moderate to low (rated 2/5).

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Acai berry
Ajoene
Akkermansia muciniphila
algal oil
Alpha-carotene
alpha-linolenic acid (ALA)
anthocyanins
apple
apricot
ashwagandha
astaxanthin
astragalus
barberry
barley
basil
beet
berberine
berry flavor
beta and delta tocopherols
beta caryophyllene
beta-carotene
beta-glucan
beta-sitosterol
bisabolol
black cumin
black garlic
radish
sesame
black tea
black walnut
blackberry
blueberry
branched-chain amino acids
broccoli
Brussel sprouts
burdock
butyrate triglyceride
capsaicinoids
carrot
cat's claw
catechins
caterpillar mushroom
cauliflower
chaga mushroom
champignon
cherry
chia seed
Chinese salvia root
chlorella
chlorophyll
chokeberry
cinnamon
citrus bioflavonoids
citrus oil
citrus pectin
clove
collard
conjugated linoleic acid (CLA)
cordyceps
cowage seed
cryptoxanthin
turmeric
curcumin
d-alpha tocopherol
d-glucarate
daidzin
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DIM (diindolylmethane)
dong quai root
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fiber blend (proprietary)
fisetin
fish oil
fish protein
flavonols
flaxseed
folate
fruit and vegetable blend (proprietary)
gamma tocopherol
garlic bulb
genistein
genistin
ginger
ginseng
gooseberry
grape
grapefruit
Greek mountain tea
onion
green tea
greens blend (proprietary)
hesperetin
hesperidin
hibiscus
HMR lignan
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indole-3-carbinol
knotweed
jujube
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kelp
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lion's mane
lutein
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lychee
lycopene
maitake mushroom
mangosteen
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mixed carotenoids
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mustard seed
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orange
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parsley
pectin
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phellodendron amurense
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butyric acid
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soybean
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spirulina
stigmasterol
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tributyrin
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corilagin
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diallyl sulfide
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delphinidin
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diosgenin
didymin
date
dithiolthiones
diosmetin
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fucoidan
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garlic
gallate
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hydroxytyrosol
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isodon rubescens
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isoflavones
isoquinoline alkaloids
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long pepper
icariin
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limonene
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lotus
Leptadenia
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mangiferin
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Marine protein
Melia
Monoterpenes
Myricetin
Milk Protein
Mesima
mangostin
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Mondo grass
malvidin
mangostanol
mangostene xanthone
Marine fat
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marigold
magnolol
Mushroom
Maclura tricuspidata
Millettia
Mayapple
Maytenus ilicifolia
Momordicosides
Macaranga indica
Neoandrographolides
Naringenin
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Nigella seed
Nobiletin
Nomilin
Oroxylum indicum
Oleuropein
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oolong tea
Oligosaccharides
Onosma bracteatum
Osmanthus
Osthole
Phycocyanin
Propolis
Phellodendron
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Puerarin
Phenylpropanoids
Phytoecdysteroid
Phaeophyceae
polysaccharides
pagoda tree
polyporous mushroom
procyanidin
Pentacyclic triterpenoids
phlorotannins
Piceid
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proanthocyanidins
Propionibacterium freudenreichii
Pepper
Paris polyphylla
Pansit-pansitan
Pleurotus eryngii
Pyrrosia
Phthalides
Podophyllum
Portulaca
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Periwinkle
Phenethyl isothiocyanate (PEITC)
Polygonatum
Persimmon
punicalagins
Physalis angulata
punicic acid
punicosides
Phytoestrogens
Pokeweed
Pistachio
polymethoxylated flavones
Polygonum
parthenolide
Petiveria
rosmarinic acid
Rubiaceae
Rhabdosia rubescens
Rubia yunnanensis
Rosa roxburghii
rhubarb
Sapogenin
Sichuan Lovage
Sophora
Sesbania
Selaginella
Sete sangrias
Smartweed
Sesquiterpenes
Soy
Selenocysteine
Selenomethionine
Schizophyllum commune
Solanum indicum
Salmon Oil
Salidroside
Silybin
Syringic acid
Salvianolic acid
Sinigrin
Shogaol
Soy Protein
Schisandrins
Semecarpus anacardium
saponins
Sotetsuflavone
Sulfated polysaccharide
Shilajit
Sargassum
Sword Bean
S-allylcysteine
Sesamin
Sinensetin
Stilbenoid
Sulforaphane
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Tea
Thymoquinone
Tumerone
Thymus
Taxifolin
Thistle
Triterpenes
Typhonium flagelliforme
Tangeretin
Tanshinone
Tiliroside
Theaflavin
Turmerones
Taraxasterol
Tulbaghia
Trametes
Thiosulfinate
Tylophorine
Tremella
Uncaria
Ursolic Acid
Vestitol
Vegetable Protein
Vine tea
Vitexin
Viniferin
Vicenin
Verbascoside
Withanolides
White Tea
Wax Gourd
Wogonin
Wakame
Water Pepper
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Xanthohumol
Xanthophyll
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Xylaria nigripes
Xanthone
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Yacon
Yumberry
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Zedoary
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Products containing vitamin D3

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Evidence supporting the use of: Vitamin D3
For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the health condition: Cancer (prevention)

Table of Contents

Synopsis

Other ingredients used for Cancer (prevention)

Other health conditions supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Cancer (prevention)