Relationship: Cancer Treatment (reducing side effects) and alpha lipoic acid

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Cancer Treatment (reducing side effects)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis
Other ingredients for this health condition
Other health conditions supported by this ingredient
Products containing this ingredient

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) has been investigated for its potential to reduce certain side effects of cancer treatment, particularly chemotherapy-induced peripheral neuropathy (CIPN). Some preclinical studies and small clinical trials suggest that ALA, due to its antioxidant properties, may help protect nerves from the oxidative damage often caused by chemotherapeutic agents like cisplatin and paclitaxel. Observational and pilot studies have reported possible improvements in neuropathic symptoms and nerve conduction in patients given ALA supplements. For example, a few randomized controlled trials (RCTs) have examined the use of ALA in patients with CIPN, with mixed results—some finding modest benefits and others showing no significant effect compared to placebo.

However, the overall quality and size of these studies remain limited, and systematic reviews (such as those published in Supportive Care in Cancer and the Cochrane Database of Systematic Reviews) generally conclude that current evidence is insufficient to recommend ALA as a standard therapy for chemotherapy side effects. Additionally, there is concern that antioxidants like ALA could potentially reduce the effectiveness of certain chemotherapies by interfering with oxidative mechanisms meant to damage cancer cells, although this risk remains theoretical and not clearly proven in clinical studies. In summary, while there is some scientific rationale and early clinical data supporting the use of alpha lipoic acid to mitigate side effects of cancer treatment, the evidence is not yet robust, and further large-scale, well-designed trials are needed.

More about alpha lipoic acid
More about Cancer Treatment (reducing side effects)

Other ingredients used for Cancer Treatment (reducing side effects)

acetyl l-carnitine
akkermansia muciniphila
algal oil
aloe vera
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
astragalus
bacillus coagulans
bacillus subtilis
basil
beet
berberine
berry flavor
beta caryophyllene
Beta-Glucan
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium lactis
bifidobacterium longum
black cumin
sesame
blackberry
blueberry
Indian frankincense
branched-chain amino acids
broccoli
bromelain
bupleurum falcatum
burdock
butyrate triglyceride
cannabis sativa oil
capsaicinoids
cat's claw
catalase
caterpillar mushroom
chaga mushroom
chamomile
Chinese salvia root
chlorella
chlorophyll
chokeberry
citrus oil
citrus pectin
coating
coenzyme Q10 (CoQ10)
colostrum
cordyceps
turmeric
curcumin
cuspidatum root
cyclodextrin
d-alpha tocopherol
d-glucarate
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DIM (diindolylmethane)
dong quai root
DPA (docosapentaenoic acid)
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fiber blend (proprietary)
fisetin
fish oil
flavonols
flaxseed
folate
garlic bulb
genistein
ginger
ginseng
green tea
hemp oil
hesperetin
hesperidin
HMR lignan
Indian tinospora
indole-3-carbinol
iron
knotweed
jujube
kale
l-carnitine
l-cysteine
l-glutamine
l-glutathione
lactobacillus acidophilus
lactobacillus brevis
lactobacillus casei
lactobacillus fermentum
lactobacillus gasseri
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus salivarius
lactoferrin
lentinula edodes mycelia
lion's mane
lycopene
magnesium
maitake mushroom
mangosteen
marine lipid
medium chain triglycerides (MCT)
melatonin
milk
milk thistle
mixed carotenoids
moringa
n-acetyl-cysteine (NAC)
nettle
niacinamide (vitamin B3)
oleanolic acid
omega-3 fatty acids
ornithine alpha-ketoglutarate
oyster mushroom
pectin
perilla
phenolic acids
phospholipids
phytocannabinoids
phytosterols
plum fruit
pollen
pomegranate
prebiotic blend (proprietary)
protease
protein
pumpkin
raspberry
reishi mushroom
resveratrol
rhizome
rosemary
rutin
scrophularia root
selenium
shiitake mushroom
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spirulina
sulforaphane glucosinolate
tocotrienols
tributyrin
triphala
turkey tail mushroom
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vitamin A
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
water
wheat grass
whey protein
zinc
sarsaparilla
yellow root
suma
jiaogulan
typhonium
atractylodes
papaya
neem tree
smilax
tinospora cordifolia
rubia cordifolia
peony
lingzhi
lingusticum wallichii
boxthorne
buckthorn
pau d'arco
lemongrass
myrrh
ferulic acid
chrysanthemum
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
trichosanthes
royal jelly
polyphenols
purslane
coix
polyporus
aster root
noni
biota seed
nopal
goji berry
paw paw
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
soy isoflavones
ashitaba
soursop
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-Hydroxyandrostenedione
5-methyltetrahydrofolate glucosamine
Agarikon Mushroom
Alpha Glucans
Angelica
Apigenin
Antrodia camphorata
Auricularia
Anamu
Artesunate
AHCC
Andrographolide
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Andrographis
Ampelopsin
Acemannan
Algal protein
Arabinoxylan
Arisaema
Alantolactone
Anti-aromatase
Artepillin C
Atractylone
Bee Propolis
Black Seed
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Baphicacanthus cusia
Bidens pilosa
Betulinic acid
Brassica
Boswellic Acid
Beef liver
Baccosides
Baicalein
Beta-lapachone
Bee hive
Bael
Basidiomycota
berry
Boswellia
Butein
Bifidobacterium animalis
Bee products
Black Nightshade
Bacteria
Bifidobacteria
BCAA
Baicalin
Boerhavia diffusa
Borneol
Caffeic Acid
Camellia sinensis
Caryophyllene
Calendula
Chinese Mountain Ant
Condurango
Chlorophyllin
Coriolus mushroom
Capillary Artemisia
Chinese Fleeceflower
Curcuminoid
Citrus
Chinese Pond Turtle
Cancerina
Curcumen
Centella asiatica
Curcuma
Carnosol
C-Phycocyanin
Chirata
Crinum latifolium
Cannabidiol
Clostridium butyricum
Corilagin
Crocetin
Cytokines
Costus
Celosia
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Diallyl sulfide
DNA
Decursin
Daidzein
Diosgenin
Didymin
Date
Dithiolthiones
Diosmetin
Eupolyphaga sinensis
Eclipta
Eicosapentaenoic Acid
Essential Oil Blend
Enokitake
Folic Acid
Fiber
Flavonoids
Flavonones
Flammulina velutipes
fibroblast growth factor
Garlic
Isoflavones
Mallow
Milk Protein
Mistletoe
Periwinkle
Soy Protein
Zucchini

Products containing alpha lipoic acid

Health Concerns

Brands

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Cancer Treatment (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

Health Concerns

Brands

Evidence supporting the use of: Alpha lipoic acidFor the health condition: Cancer Treatment (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Cancer Treatment (reducing side effects)