Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-caryophyllene is a natural bicyclic sesquiterpene found in many essential oils, including those from black pepper, cloves, and cannabis. Its use in supporting cancer treatment, particularly in reducing side effects, is primarily justified by emerging scientific evidence rather than longstanding traditional use. Preclinical (in vitro and animal) studies suggest that beta-caryophyllene has anti-inflammatory, analgesic, and cytoprotective properties, which may help mitigate certain chemotherapy-induced side effects such as neuropathic pain and gastrointestinal toxicity. For example, some studies report that beta-caryophyllene can attenuate inflammation and oxidative stress in animal models, potentially reducing tissue damage caused by chemotherapy drugs. Additionally, beta-caryophyllene is a selective agonist of the CB2 cannabinoid receptor, which is linked to immune modulation and pain control without the psychoactive effects of CB1 agonists. However, robust human clinical trials are lacking, and most supportive data come from laboratory research or animal models. Thus, while the scientific rationale is promising and some initial results are encouraging, the overall evidence is preliminary and does not yet justify widespread clinical use for this purpose. More rigorous clinical studies are needed to establish efficacy and safety in cancer patients. As such, the strength of the evidence is rated as 2 out of 5.

More about beta caryophyllene
More about Cancer Treatment (reducing side effects)

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by beta caryophyllene

Products containing beta caryophyllene