Evidence supporting the use of: Flax lignans
For the health condition: Cancer Treatment (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flax lignans, particularly secoisolariciresinol diglucoside (SDG), have been studied for their potential supportive role in cancer treatment, mainly due to their phytoestrogenic and antioxidant properties. Several small clinical trials and observational studies have explored the impact of flaxseed or flax lignans on cancer patients, particularly those with breast or prostate cancer. Some evidence suggests that flax lignans may help reduce certain side effects of cancer treatment, such as hot flashes and menopausal symptoms in breast cancer patients, and may possibly modulate hormone metabolism. However, most clinical studies are limited by small sample sizes, short durations, and lack of rigorous controls.

Preclinical research indicates that flax lignans can influence estrogen metabolism, inhibit tumor cell proliferation, and reduce oxidative stress. While these mechanisms are promising, robust clinical data directly supporting the use of flax lignans to mitigate side effects of cancer therapy are limited. The American Institute for Cancer Research and other major cancer organizations do not specifically endorse flax lignans as a standard supportive care intervention, though they acknowledge its safety as part of a healthy diet.

In summary, there is preliminary scientific evidence suggesting a potential benefit of flax lignans in reducing some side effects of cancer treatment, but the evidence is not strong or conclusive. Larger, well-designed clinical trials are needed to confirm these effects and inform clinical recommendations.

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Products containing Flax lignans

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