Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-glutathione, a tripeptide composed of glutamine, cysteine, and glycine, is recognized for its antioxidant properties and its role in cellular detoxification. In the context of cancer treatment, L-glutathione has been studied primarily for its ability to reduce the side effects of chemotherapy, particularly neurotoxicity associated with platinum-based drugs such as cisplatin and oxaliplatin. Several clinical studies and meta-analyses have shown that intravenous glutathione administered alongside chemotherapy can decrease the incidence and severity of peripheral neuropathy, a common and often dose-limiting side effect of these agents. For example, a 2014 meta-analysis in Supportive Care in Cancer concluded that glutathione supplementation was associated with a significant reduction in neuropathy without compromising the anticancer efficacy of chemotherapy.

However, the overall quality and number of studies are moderate, and there is some variability in dosing regimens and administration protocols. Glutathione does not directly treat cancer, but rather is used adjunctively to support patients by mitigating certain toxicities. Major oncology guidelines recognize glutathione as an option for reducing chemotherapy-induced neurotoxicity, especially when other interventions are ineffective or not tolerated.

In summary, there is scientific evidence, though not overwhelmingly strong, supporting the use of L-glutathione to reduce specific chemotherapy side effects. Its use is generally well-tolerated, but further large-scale, high-quality studies are needed to establish optimal protocols and confirm long-term safety.

More about L-glutathione
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