Evidence supporting the use of: Ostarine
For the health condition: Cancer Treatment (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Ostarine (also known as MK-2866 or Enobosarm) is a selective androgen receptor modulator (SARM) that has been investigated for its potential to combat muscle wasting (cachexia) associated with cancer and other chronic diseases. The scientific rationale for its use is based on its ability to selectively stimulate androgen receptors in muscle and bone, thereby promoting lean body mass and physical function without many of the undesirable side effects of traditional anabolic steroids.
Several clinical studies have examined Ostarine in cancer patients suffering from muscle wasting. For example, a Phase II clinical trial (Dobs et al., 2013, J Cachexia Sarcopenia Muscle) demonstrated that Enobosarm improved total lean body mass and physical function in patients with cancer cachexia. However, later Phase III trials (POWER 1 and 2) failed to meet their primary endpoints for significant functional improvement, though increases in lean body mass were still observed.
Ostarine is not FDA-approved for this indication, but it has a scientific basis for its potential use in mitigating cancer-related muscle loss. The evidence is moderate: early trials were promising, but larger, more definitive studies have produced mixed results. It is not used traditionally, and its use in this context rests on scientific investigation rather than historical precedent. Overall, Ostarine shows promise but is not yet an established or approved therapy for cancer-related side effects.
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