Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Protease enzymes, including bromelain, papain, and mixtures such as serrapeptase, have been explored as adjuncts in cancer treatment, primarily for their potential to reduce side effects related to chemotherapy and radiation therapy. The scientific rationale is based on proteases' ability to break down proteins, which can help mitigate inflammation, reduce edema, and potentially promote faster healing of damaged tissues. Several small clinical studies and some animal research have investigated proteases for reducing mucositis, lymphedema, and tissue swelling that can occur during cancer therapies. For example, bromelain has demonstrated anti-inflammatory and analgesic properties in certain settings, and a few studies suggest it may reduce oral mucositis severity in patients undergoing chemotherapy. However, the evidence remains limited, with mixed results and a lack of large, high-quality randomized controlled trials. Meta-analyses and systematic reviews typically cite low certainty of benefit, significant heterogeneity in study design, and possible publication bias. Mechanistically, there is some interest in proteases for their potential to enhance immune function or alter tumor microenvironments, but robust clinical evidence for these effects is lacking. Therefore, while there is some scientific investigation and limited supportive data, the overall quality and consistency of the evidence are modest, and major oncology guidelines do not currently recommend proteases as standard supportive care in cancer treatment. Patients should consult their healthcare provider before using protease supplements, as interactions with cancer therapies are possible.

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Other ingredients used for Cancer Treatment (reducing side effects)

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Products containing protease

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Integrative Therapeutics Similase GFCF
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Metagenics SpectraZyme Pan 9x
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Pure Encapsulations Systemic Enzyme Complex
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Douglas Laboratories Ultra Protein Green
Vitabase Ultra Veggie Enzymes