Evidence supporting the use of: Schizophyllum
For the health condition: Cancer Treatment (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Schizophyllum commune, a common medicinal mushroom, is used in cancer treatment support primarily due to its polysaccharide component known as schizophyllan (also called Sonifilan or SPG). There is moderate scientific evidence supporting its use as an adjunct to cancer therapy, especially in Japan and some other Asian countries where it has been licensed and used clinically since the 1980s. Schizophyllan is a beta-glucan that has demonstrated immunomodulatory activity, particularly in enhancing host immune responses.
Clinical trials and studies suggest that schizophyllan can improve the effectiveness of chemotherapy and radiation therapy, especially in cancers such as head and neck, gastric, and cervical cancers. Its primary benefit appears to be the reduction of side effects associated with anti-cancer treatments (like leukopenia), and the potential improvement of quality of life and survival rates in certain patient populations. However, its benefits are considered modest, and not all studies report significant clinical outcomes.
Schizophyllan is thought to stimulate immune cells, including macrophages and T-cells, thereby enhancing anti-tumor immune responses. Regulatory approval and medical use in Japan, with some randomized controlled trials, underpin its scientific validation. However, the evidence base is not robust enough for widespread global acceptance, and its use is generally as an adjunct rather than a primary therapy. Meta-analyses and systematic reviews highlight that while promising, high-quality, large-scale clinical trials are still needed to confirm its efficacy and safety profile.
More about Schizophyllum
More about Cancer Treatment (reducing side effects)
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Other health conditions supported by Schizophyllum
Cancer (natural therapy for)Cancer (prevention)
Cancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Inflammation