Relationship: Cancer Treatment (reducing side effects) and selenium

Evidence supporting the use of: Selenium
For the health condition: Cancer Treatment (reducing side effects)

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Source of validity: Scientific
Rating (out of 5): 2

Selenium is a trace element that has been studied for its potential role in cancer prevention and as an adjunct to cancer treatment, particularly for mitigating the side effects of chemotherapy and radiotherapy. The scientific evidence supporting selenium’s use in this context is mixed and generally considered weak to moderate. Some randomized controlled trials and meta-analyses have suggested that selenium supplementation may reduce the severity of certain side effects, such as oral mucositis in head and neck cancer patients receiving radiotherapy, and may help maintain immune function during treatment. Proposed mechanisms include selenium's antioxidant properties, its role in selenoproteins that reduce oxidative stress, and support of immune system function.

However, other large trials, such as the SELECT trial (Selenium and Vitamin E Cancer Prevention Trial), failed to demonstrate a benefit of selenium supplementation for cancer prevention and raised concerns about possible harm, such as increased risk of type 2 diabetes with high-dose supplementation. Most guidelines do not recommend routine selenium supplementation during cancer therapy, except in cases of documented deficiency. While there is some scientific rationale and limited evidence for selenium’s supportive use, the overall evidence is not strong, and its use should be individualized and discussed with a healthcare provider. Further research is needed to clarify its role and identify which patients, if any, might benefit.

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Evidence supporting the use of: Selenium
For the health condition: Cancer Treatment (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by selenium

Products containing selenium

Health Concerns

Brands

Evidence supporting the use of: SeleniumFor the health condition: Cancer Treatment (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Cancer Treatment (reducing side effects)

Other health conditions supported by selenium

Products containing selenium

Evidence supporting the use of: Selenium
For the health condition: Cancer Treatment (reducing side effects)