Evidence supporting the use of: Vitamin B12 (various)
For the health condition: Cancer Treatment (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 is sometimes used alongside cancer treatment, primarily to address or prevent side effects such as anemia and peripheral neuropathy that may result from chemotherapy or radiation. The scientific rationale is based on the well-established role of vitamin B12 in red blood cell formation and nervous system health. Chemotherapy agents, such as platinum-based compounds and certain antimetabolites, can impair blood cell production or cause nerve damage, and patients with underlying or treatment-induced B12 deficiency are at greater risk for these complications.

There is moderate scientific evidence supporting vitamin B12 supplementation for correcting deficiency and thus reducing the incidence or severity of treatment-related anemia and neuropathy. For example, studies have shown that supplementation of B12, sometimes in combination with folate, can reduce the risk of hematologic toxicity in patients receiving pemetrexed-based chemotherapy for lung cancer. However, there is limited evidence that B12 supplementation benefits cancer patients who are not deficient in the vitamin, and there is no evidence that B12 directly treats cancer or reduces the primary side effects of cancer therapy in the absence of deficiency.

Clinical guidelines recommend monitoring and correcting B12 deficiency in cancer patients, especially those with symptoms of anemia or neuropathy. Routine supplementation without evidence of deficiency is not advised. Thus, while B12 is not a cancer treatment, its use to reduce certain side effects in deficient patients is scientifically validated.

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Products containing Vitamin B12 (various)

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