Evidence supporting the use of: Diclofenac
For the health condition: Canker Sores

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that has been investigated for its efficacy in treating canker sores (aphthous ulcers). The rationale for its use is grounded in its anti-inflammatory and analgesic properties, which can alleviate pain and reduce local inflammation. Several studies, including randomized controlled trials, have evaluated the topical application of diclofenac, often in the form of a mouthwash or mucoadhesive patch, for aphthous ulcer management.

Clinical evidence suggests that topical diclofenac, particularly when combined with hyaluronate (e.g., 3% diclofenac in 2.5% hyaluronate), can reduce pain and promote healing in minor aphthous ulcers. A notable example is a double-blind, randomized, placebo-controlled study published in Oral Diseases (2002) which demonstrated significant pain reduction and accelerated healing in patients using diclofenac/hyaluronate oral patches compared to placebo. Similar findings have been reported in other small-scale studies, but the quantity and quality of research is still limited compared to more established treatments like corticosteroids.

Overall, the evidence supporting diclofenac’s use for canker sores is moderate and based on scientific studies, but it is not yet considered a first-line therapy. The use is not based on traditional medicine, but rather on its pharmacological properties and clinical research. More large-scale, high-quality trials are needed to further establish its efficacy and safety profile for this indication.

More about Diclofenac
More about Canker Sores

Other ingredients used for Canker Sores

aloe vera
bamboo
basil
myrobalan
betel
bisabolol
blackberry
bасора
chamomile
clove
coating
coconut milk
Coptis chinensis
curcumin
dog rose
folate
ginger
horseradish
lactobacillus reuteri
lactobacillus salivarius
lactoperoxidase
lemon
licorice root
magnesium
milk
mustard seed
spruce
omega-3 fatty acids
oregano
oregon grape
parsley
peppermint oil
pineapple
plantain
rhizome
sage
schizonepeta
scrophularia root
slippery elm bark
sphaeranthus indicus
thyme
triphala
vitamin B12
vitamin C
zinc
yellow root
squawvine
chickweed
typhonium
xanthium (cockleburs)
papaya
neem tree
nut grass
clerodendrum indicum
ferula assafoetida
commiphora
blackboard tree
boxthorne
buckthorn
lemongrass
myrrh
siler root
hyacinth bean
morinda
oriental arborvitae
trichosanthes
zanthoxylum
sheep's sorrel
eucalyptus
menthol oil
aster root
paw paw
herbal blend (proprietary)
indigo leaves
Ash
Avens
Agastache
Ardisia
acacia
Agrimony
Achyranthes
Anamu
American Liverleaf
Agrimonia pilosa
Asteracea
Acemannan
Amor seco
Arisaema
Bee Propolis
Bermuda Grass
Blue Flag
Bai Ji
Baphicacanthus cusia
Bidens pilosa
Blackthorn
Bicarbonate
Balsam
Bishop's Weed
Bayleaf
Black galingale
Barleria
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Bloodroot
Banyan
Bee products
Black Nightshade
Bombax
Borassus aethiopum
Bacteria
Bassia scoparia
Borneol
Coconut
Curry leaf
Calendula
Clerodendrum trichotomum
Chlorophyllin
Carvacrol
Capillary Artemisia
Citron
Capsaicin
Cajuput
Chinese Raisintree
Cowherb
Centipeda
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Corktree
Collinsonia
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DIVI-DIVI
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European Elder
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European-Five Finger Grass
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Eugenol
Galangal
Little ironweed
Mustard
Mallow
Oak
Rose
Snakeroot (unspecified)
Sandalwood
Sumac

Products containing Diclofenac

We currently have no products on Vitabase that contain this ingredient.