Evidence supporting the use of: Anthocyanidins (unspecified)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanidins are a class of flavonoids commonly found in berries and other pigmented fruits and vegetables. Their use to support capillary health is backed by a moderate level of scientific evidence. Several studies have demonstrated that anthocyanidins possess antioxidant properties, which help protect blood vessels, including capillaries, from oxidative stress and inflammation. Experimental and clinical investigations, particularly those focusing on extracts from bilberry (Vaccinium myrtillus), have shown improvements in capillary resistance and reduced capillary permeability in both animal models and humans. A number of these studies support the use of anthocyanidin-rich extracts for conditions like chronic venous insufficiency and microvascular fragility.

However, while these effects have been observed, much of the research has been conducted on anthocyanidin-containing extracts (such as those from bilberry or grape seed) rather than on isolated anthocyanidins. Therefore, while the collective evidence for anthocyanidins as a group is promising, the evidence for unspecified or isolated anthocyanidins is less robust. The overall strength of evidence is moderate, supporting a rating of 3. More high-quality, large-scale clinical trials are needed to clarify the exact benefits and effective doses of anthocyanidins for capillary support.

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