Evidence supporting the use of: Apocynin
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Apocynin is a natural compound derived from the root of Picrorhiza kurroa and other plants. It has been studied primarily for its ability to inhibit NADPH oxidase, an enzyme complex involved in the production of reactive oxygen species (ROS). Excessive ROS are implicated in oxidative stress, which can contribute to endothelial dysfunction and increased capillary permeability. Several in vitro and animal studies have shown that apocynin can reduce oxidative stress and inflammation in blood vessels, thereby potentially protecting capillary structure and function. For example, research published in journals such as Cardiovascular Research and Free Radical Biology & Medicine has demonstrated that apocynin administration can improve endothelial function and decrease vascular leakage in models of hypertension and diabetes.

However, while these preclinical findings are promising, human clinical trials directly assessing apocynin’s effect on capillary health are limited. Most evidence comes from animal or cell culture models, and the translation of these results to human capillary health remains to be firmly established. Thus, while the scientific rationale exists and there is supportive experimental evidence, the quality and quantity of human data are not sufficient to rate the evidence higher than moderate (3/5).

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Products containing apocynin

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