Evidence supporting the use of: Baicalein
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Baicalein is a flavonoid compound derived from the roots of Scutellaria baicalensis (Chinese skullcap), a plant widely used in traditional Chinese medicine. In recent years, scientific studies have investigated baicalein’s potential benefits for vascular health, including its effects on capillaries. Preclinical research has demonstrated that baicalein exhibits significant antioxidant, anti-inflammatory, and anti-angiogenic properties. These effects can help protect endothelial cells lining the capillaries from oxidative stress and inflammation, which are key factors in the development of microvascular dysfunction.

For example, in vitro studies have shown that baicalein can inhibit reactive oxygen species (ROS) production and reduce endothelial cell permeability, which is relevant to maintaining healthy capillary integrity. Animal studies suggest that baicalein may ameliorate capillary leakage and support microcirculatory health, especially in models of diabetes and inflammation. However, there is a lack of large-scale human clinical trials directly investigating baicalein’s effects specifically on capillary health. The evidence base is therefore promising but largely limited to laboratory and animal models.

Overall, while there is a traditional basis for the use of Scutellaria baicalensis in vascular and inflammatory conditions, the justification for baicalein specifically in supporting the capillary system is primarily scientific, with a moderate level of preclinical evidence but limited direct clinical validation. Thus, the strength of evidence is rated at 3 out of 5.

More about baicalein
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Products containing baicalein

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