Evidence supporting the use of: Centella asiatica
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Centella asiatica (commonly known as gotu kola) is traditionally used in many cultures for wound healing and circulatory support. In recent decades, scientific research has specifically examined its effects on the capillaries and microcirculation. Several clinical studies and reviews support its use for chronic venous insufficiency, a condition related to compromised capillary function, and for improving symptoms such as edema, heaviness, and pain in the legs.

The active compounds in Centella asiatica, primarily triterpenoids such as asiaticoside and madecassoside, have been shown to enhance collagen synthesis and strengthen the walls of blood vessels. This is believed to increase capillary resistance and reduce capillary permeability, thereby decreasing leakage and swelling. Several randomized controlled trials have found statistically significant benefits in objective markers of microcirculation (such as transcapillary filtration rate) and subjective symptoms in patients with venous disease.

Systematic reviews and meta-analyses (see: Belcaro et al., 2013; Maquart et al., 1999) confirm that Centella asiatica extracts (often standardized as TTFCA—total triterpenic fraction of Centella asiatica) can benefit microcirculatory health, particularly in the context of venous hypertension and associated capillary dysfunctions. While more large-scale, high-quality studies could further clarify the effects, the existing scientific evidence gives a strong rationale for its use to support the capillary system.

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