Centella triterpenes, also known as centelloids or asiaticosides, are active compounds derived from the plant Centella asiatica. There is a growing body of scientific evidence supporting the use of Centella triterpenes for vascular health, particularly in supporting capillary integrity and microcirculation. Several clinical studies and reviews have investigated their effects on chronic venous insufficiency, microangiopathy, and capillary permeability.

The mechanism appears to involve stimulation of collagen synthesis and modulation of endothelial function, resulting in strengthened capillary walls and reduced capillary hyperpermeability. A 2001 review in “Angiology” summarized multiple randomized controlled trials demonstrating that Centella triterpenes significantly reduce edema, improve subjective and objective symptoms of venous insufficiency, and enhance capillary filtration rate. Other studies have shown improvements in microcirculatory parameters in patients with diabetic microangiopathy and scleroderma.

Safety profiles in clinical studies are generally favorable, with few adverse effects reported. While more large-scale, high-quality trials are warranted, the available evidence from both mechanistic and clinical studies supports the use of Centella triterpenes as a vascular protectant, especially for capillary fragility and venous insufficiency.