Evidence supporting the use of: Eicosapentaenoic acid
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eicosapentaenoic Acid (EPA) is an omega-3 polyunsaturated fatty acid predominantly found in fish oil. Scientific research suggests that EPA contributes to cardiovascular health through several mechanisms, some of which may benefit the capillaries specifically. EPA possesses anti-inflammatory and anti-thrombotic properties, which help maintain endothelial function and vascular integrity. The endothelium lines all blood vessels, including capillaries, and its dysfunction is a key factor in microvascular diseases and capillary fragility.

Several clinical studies and meta-analyses have found that omega-3 fatty acids, including EPA, promote improved endothelial function, reduce blood viscosity, and may decrease capillary leakage in conditions such as diabetic microangiopathy. While most research has focused on macrovascular outcomes (such as coronary artery disease), a subset of studies indicates that EPA can help reduce inflammation and oxidative stress in the microvasculature, potentially supporting capillary health and resilience.

However, direct evidence specifically targeting EPA’s effect on capillaries, independent of other cardiovascular effects, is limited. The rating of 3 reflects moderate scientific support: while mechanisms and some clinical findings are promising, more targeted research is needed to conclusively establish EPA’s efficacy for supporting capillary structure and function.

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