Evidence supporting the use of: Flavanones (various)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavanones, a subclass of flavonoids found abundantly in citrus fruits (such as hesperidin, naringin, and eriocitrin), have been studied for their beneficial effects on the vascular system, including capillary health. Several clinical and preclinical studies support their use in strengthening capillaries and improving microcirculation. Hesperidin, in particular, is often included in formulations for chronic venous insufficiency and capillary fragility. Evidence suggests that flavanones exert protective effects by reducing capillary permeability, strengthening capillary walls, and exhibiting anti-inflammatory and antioxidant properties. These actions help to prevent microvascular leakage and support overall capillary integrity.

Randomized controlled trials with hesperidin and related compounds indicate improvements in symptoms such as leg swelling, heaviness, and visible capillary fragility. Reviews published in journals such as Phytotherapy Research and the Journal of Clinical Medicine summarize both mechanistic and clinical evidence for these effects. Additionally, the European Medicines Agency has recognized certain flavanone-rich extracts as traditional herbal medicines for the relief of symptoms related to venous insufficiency.

While more high-quality clinical research is warranted for some specific flavanones, the current body of evidence, both experimental and clinical, justifies their use to support capillary health.

More about Flavanones (various)
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Products containing Flavanones (various)

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