Evidence supporting the use of: Flavonoid
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavonoids are a class of polyphenolic compounds found abundantly in fruits, vegetables, and certain beverages like tea and wine. Their use to support capillary health is primarily justified by scientific evidence. Flavonoids have been shown in multiple studies to strengthen capillary walls, reduce capillary fragility, and improve microcirculation. One of the best-studied flavonoids in this context is diosmin, often used in combination with hesperidin. Clinical trials and meta-analyses have demonstrated that these compounds can reduce symptoms of chronic venous insufficiency, such as leg swelling, heaviness, and discomfort. The mechanism is thought to involve antioxidant activity, inhibition of inflammatory mediators, and direct effects on vascular endothelium, leading to improved tone and permeability of capillaries. Additionally, flavonoids like rutin and quercetin have demonstrated similar protective effects on capillaries in both animal and human studies. While not all flavonoids have the same potency or efficacy, the overall body of evidence supports their role in maintaining capillary integrity and function. However, while the evidence is robust for certain flavonoids, it is not universal across all compounds in this class, and results can vary based on formulation, dosage, and individual response.

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