Evidence supporting the use of: Flavonoid glycosides
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavonoid glycosides are compounds found in many plants, including citrus fruits, buckwheat, and horse chestnut. They have been widely studied for their effects on vascular health, particularly their ability to support capillary integrity. Scientific evidence indicates that certain flavonoid glycosides, such as rutin and diosmin, can strengthen capillary walls, reduce capillary permeability, and improve microcirculation. These effects are attributed to their antioxidant properties and their ability to inhibit enzymes that degrade the extracellular matrix of blood vessels.

Several clinical studies have demonstrated the efficacy of flavonoid glycosides in reducing symptoms of chronic venous insufficiency, such as edema, pain, and heaviness in the legs. For example, diosmin (often combined with hesperidin) has been shown in randomized controlled trials to improve capillary resistance and decrease capillary leakage. Similarly, rutin supplementation has been observed to reduce capillary fragility and hemorrhages in people with disorders such as easy bruising or chronic venous disease.

While the bulk of evidence comes from studies on specific flavonoid glycosides rather than the group as a whole, the general consensus is that these compounds play a beneficial role in supporting capillary health, particularly in conditions characterized by increased capillary fragility or permeability. Thus, the use of flavonoid glycosides for capillary support is justified by scientific research, although the strength of evidence varies depending on the specific compound and condition studied.

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