Evidence supporting the use of: Flavonoid (unspecified)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavonoids are a class of polyphenolic compounds found widely in fruits, vegetables, and certain beverages such as tea and wine. Their use to support the capillaries and overall vascular health is backed by a significant body of scientific research. Flavonoids, especially subclasses like flavonols, flavan-3-ols, and anthocyanins, have been shown in in vitro, animal, and human studies to possess vasoprotective properties. These compounds exhibit antioxidant, anti-inflammatory, and vasodilatory effects, which contribute to strengthening capillary walls, reducing capillary permeability, and improving microcirculation. Clinical studies, particularly with flavonoid-rich extracts such as diosmin, hesperidin, and rutin, have demonstrated efficacy in reducing symptoms of chronic venous insufficiency, such as leg swelling and capillary fragility. Meta-analyses and systematic reviews support the use of certain flavonoids in reducing capillary permeability and improving venous tone. However, the evidence is stronger for specific, well-characterized flavonoids rather than the broad, unspecified category. While the precise mechanisms are still being elucidated, existing data justify the use of flavonoids to support capillary health, especially in individuals with mild vascular disorders. It is important to note that while scientific validation is substantial, not all flavonoids or sources have been equally studied, so product standardization and specific flavonoid identification enhance efficacy and reliability.

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