Evidence supporting the use of: Flavonones (unspecified)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavanones are a subclass of flavonoids, a group of polyphenolic compounds widely found in citrus fruits such as oranges, lemons, and grapefruits. There is moderate scientific evidence supporting the use of flavanones in supporting capillary health. Several studies have demonstrated that flavanones such as hesperidin and naringenin exhibit vasoprotective effects. For example, hesperidin has been shown to strengthen capillary walls, reduce capillary permeability, and exert anti-inflammatory effects, which are beneficial for the maintenance of microvascular integrity. Clinical trials, particularly those using citrus extracts enriched in flavanones, have reported improvements in capillary fragility and a reduction in symptoms such as easy bruising and swelling, especially in individuals with chronic venous insufficiency.

The proposed mechanisms include antioxidant activity, modulation of endothelial function, and inhibition of enzymes that degrade connective tissue in vessel walls. However, while there is a growing body of data, much of the clinical evidence is derived from studies on specific flavanones (e.g., hesperidin, diosmin) rather than the broader category of "flavanones (unspecified)." Thus, while the use of flavanones to support capillary health is grounded in scientific evidence, the strength of the evidence is moderate and more pronounced for certain well-studied compounds within this class. Further research is needed to clarify the efficacy of less-studied flavanones and to establish standardized dosing regimens.

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