Evidence supporting the use of: Pentacyclic triterpenoids
For the body system: Capillaries

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Pentacyclic triterpenoids are a class of naturally occurring compounds found in many plants, including Centella asiatica (gotu kola), horse chestnut, and olive leaves. Their use to support capillary health is primarily rooted in traditional and historical herbal medicine. For example, Centella asiatica, rich in pentacyclic triterpenoids such as asiaticoside and madecassoside, has long been used in Ayurvedic and traditional Chinese medicine to promote wound healing and support vascular integrity. Similarly, horse chestnut seed extract, which contains the pentacyclic triterpenoid escin, has a history of use in European herbal medicine for the management of chronic venous insufficiency and to reduce capillary fragility.

While some in vitro and animal studies suggest that pentacyclic triterpenoids may help strengthen capillary walls, reduce permeability, and exhibit anti-inflammatory properties, robust clinical evidence supporting their efficacy for capillary health in humans is limited and ingredient-specific. The scientific data for the class as a whole remains sparse, though certain extracts such as horse chestnut seed do have some clinical support for improving symptoms of chronic venous insufficiency. Overall, the use of unspecified pentacyclic triterpenoids for capillary support is more justified by historical and traditional use rather than strong scientific consensus.

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