Evidence supporting the use of: Platelet derived growth factor
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Platelet-derived growth factor (PDGF) is a well-characterized signaling protein involved in various cellular processes, particularly those related to blood vessel formation and maintenance. PDGF is produced by platelets, endothelial cells, and other cell types, and acts as a potent mitogen for cells of mesenchymal origin, including pericytes and smooth muscle cells which play crucial roles in capillary stability and function. Scientific literature demonstrates that PDGF is a key mediator of angiogenesis (the formation of new blood vessels) and vascular remodeling. Specifically, PDGF-BB, one of its isoforms, recruits pericytes to newly forming capillaries, stabilizing and maturing the microvasculature. This pericyte recruitment is essential for the structural integrity and function of capillaries. Disruption of PDGF signaling has been shown in animal models to result in abnormal, leaky, or hemorrhagic capillaries due to loss of pericyte coverage. Furthermore, therapeutic applications of PDGF, such as in wound healing and tissue engineering, underscore its role in supporting capillary networks and microvascular repair. While there are no routine clinical uses of exogenous PDGF specifically for "capillary support" in healthy individuals, the scientific evidence strongly indicates that PDGF is fundamental to capillary health and function, particularly in contexts of injury or disease.

More about Platelet derived growth factor
More about Capillaries

Other body systems supported by Platelet derived growth factor

Blood
Capillaries
Circulatory System
Joints
Skeletal System (Bones)
Skin

Products containing Platelet derived growth factor

We currently have no products on Vitabase that contain this ingredient.