Evidence supporting the use of: Polydatin
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polydatin, also known as piceid, is a natural glycoside form of resveratrol found in the root of Polygonum cuspidatum and other plants. It has attracted scientific interest for its potential vasoprotective properties, including support for capillary health. Several preclinical studies have demonstrated that polydatin exhibits antioxidant, anti-inflammatory, and endothelial-protective effects. For instance, research published in Oxidative Medicine and Cellular Longevity (2019) and European Journal of Pharmacology (2016) has shown that polydatin can reduce oxidative stress and protect vascular endothelial cells from injury, which is relevant for maintaining capillary integrity and function. Animal models of vascular injury have shown reduced capillary leakage and improved microcirculation following polydatin administration. The mechanism is thought to involve inhibition of reactive oxygen species, stabilization of endothelial barriers, and modulation of nitric oxide production.

However, most of the supporting data are from in vitro or animal studies; robust human clinical trials evaluating polydatin specifically for capillary health are lacking. While its benefits for general vascular health are promising and provide a scientific rationale for its use to support the capillaries, the evidence is not yet definitive due to limited clinical validation. Thus, polydatin’s use for capillary support is justified by scientific investigation, but further research, especially in humans, is needed to confirm efficacy.

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