Evidence supporting the use of: Polymethoxylated flavones
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polymethoxylated flavones (PMFs) are a subclass of flavonoids found predominantly in citrus peels, such as those from oranges and tangerines. Scientific research indicates that PMFs, including nobiletin and tangeretin, possess notable vasoprotective properties. Several in vitro and animal studies have shown that PMFs can help support capillary health by exerting anti-inflammatory, antioxidant, and anti-angiogenic effects. These compounds stabilize endothelial cells lining the capillaries, reduce oxidative stress, and inhibit inflammatory cytokines that could otherwise weaken capillary walls. Some studies also suggest that PMFs can decrease vascular permeability and inhibit the formation of new, fragile capillaries, which is important in maintaining microvascular integrity.

While there is promising preclinical evidence, human clinical trials specifically investigating the effects of PMFs on capillary health are limited. Most available studies focus on broader cardiovascular outcomes or anti-inflammatory actions rather than direct endpoints related to capillary structure or function. Nevertheless, the mechanistic data from laboratory and animal research provide a scientific rationale for the use of PMFs in supporting the capillary (microcirculatory) system, though more robust clinical studies are needed to confirm efficacy in humans and precisely define optimal dosing and applications.

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