Evidence supporting the use of: Polyphenols (mixed)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Polyphenols, a diverse group of naturally occurring compounds found abundantly in fruits, vegetables, tea, and other plant-based foods, have been scientifically investigated for their potential benefits to the vascular system, including capillary health. Research indicates that polyphenols possess strong antioxidant and anti-inflammatory properties, which are crucial in protecting the endothelium (the inner lining of blood vessels) and maintaining capillary integrity. Several studies have demonstrated that polyphenols, particularly flavonoids (a major subclass), can improve microcirculation, reduce capillary fragility, and enhance endothelial function. For instance, clinical trials with grape seed extract and citrus bioflavonoids have shown reduced symptoms of chronic venous insufficiency and improved capillary resistance. The mechanisms attributed to these effects include scavenging of reactive oxygen species, modulation of nitric oxide production (which regulates vascular tone), and inhibition of enzymes that degrade connective tissue around capillaries. While most data come from mixed-polyphenol extracts rather than isolated compounds, the preponderance of evidence supports their role in supporting capillary health and microvascular function. However, it's important to note that the strength and consistency of the evidence can vary depending on the specific polyphenol and the formulation used.

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