Evidence supporting the use of: Proanthocyanidin (unspecified)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins are a class of polyphenols found in many plants, notably in grape seeds, pine bark, and certain berries. They are known for their antioxidant properties and have been studied for their effects on the vascular system, including capillaries. Scientific research suggests that proanthocyanidins can help strengthen capillary walls, reduce capillary permeability, and improve microcirculation. Several clinical studies—especially with grape seed extract (rich in proanthocyanidins)—have shown benefits in conditions characterized by capillary fragility, such as chronic venous insufficiency and edema. Their mechanism of action appears to involve stabilizing collagen and elastin, key structural proteins in blood vessel walls, and scavenging free radicals that can damage vascular tissues. For example, a meta-analysis published in "Phytotherapy Research" (2016) found that oligomeric proanthocyanidins significantly improved symptoms of chronic venous insufficiency, likely via capillary support. However, while the evidence is promising, much of it is based on extracts where proanthocyanidin content is specified, and data on "unspecified" proanthocyanidins are less robust. Therefore, the scientific evidence for capillary support is moderate (3/5) and strongest when the source and dosage are clearly identified.

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