Evidence supporting the use of: Vitamin B3 (Niacin)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B3, also known as niacin, has scientific evidence supporting its role in vascular health, including effects on capillaries. Niacin is well-known for its ability to improve lipid profiles by raising HDL ("good") cholesterol and lowering LDL ("bad") cholesterol and triglycerides. These lipid-modifying effects can indirectly support the health of blood vessels, including small capillaries, by reducing atherosclerotic plaque formation and improving overall circulation. Additionally, niacin induces vasodilation, which can increase blood flow to peripheral tissues, including through capillaries. This vasodilatory effect is mediated by prostaglandin release and is sometimes experienced as "niacin flush," a common side effect. Some studies suggest that niacin may improve endothelial function—the lining of blood vessels and capillaries—by reducing inflammation and oxidative stress. However, while niacin’s benefits for large vessel cardiovascular health are well documented, direct evidence for capillary-specific benefits in humans is more limited. Most of the clinical focus has been on its lipid-altering effects and prevention of major cardiovascular events, rather than direct support or repair of capillaries. In summary, niacin has a scientifically plausible mechanism for supporting vascular and capillary health, mainly through lipid modification and vasodilation. However, the evidence for direct effects on capillaries is moderate, and most health recommendations focus on its broader cardiovascular benefits rather than specific capillary support.

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