Evidence supporting the use of: Vitamin E (mixed)
For the body system: Capillaries

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E (in its mixed tocopherol forms) is primarily justified by scientific evidence to support capillary health, though the strength of evidence is moderate rather than robust. Vitamin E is a fat-soluble antioxidant that helps protect cell membranes from oxidative damage. The capillaries, being small and delicate blood vessels, are particularly susceptible to oxidative stress, which can compromise their function and structural integrity. Research has shown that Vitamin E can reduce oxidative damage to endothelial cells (which line blood vessels, including capillaries) and may improve microvascular function. Some studies have found that Vitamin E supplementation can decrease capillary fragility and improve microcirculation, especially in populations with increased oxidative stress, such as diabetics or the elderly. However, clinical trial results are mixed, with some studies showing benefit and others showing minimal or no effect. There is also some evidence from animal studies and in vitro experiments supporting Vitamin E’s role in protecting blood vessels. While Vitamin E has a long history of use as a general antioxidant supplement, its specific role in capillary health is supported by mechanistic and limited clinical data, but not at the highest level of scientific certainty.

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