Evidence supporting the use of: Vitamin E (mixed alpha-tocopherol)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (primarily alpha-tocopherol) is an antioxidant that has been studied for its role in maintaining vascular health, including the integrity of capillaries. Scientific interest in vitamin E and capillary support stems from its ability to protect cell membranes from oxidative damage, which is thought to be a factor in maintaining the strength and flexibility of blood vessels, including capillaries. Some early animal studies and small human trials suggested that vitamin E could reduce capillary fragility and permeability, potentially decreasing the risk of small bleeds or bruising, especially in populations with deficiencies.

However, the evidence in humans is limited and not robust. Most research focuses on vitamin E’s cardiovascular effects more broadly, rather than specifically on capillary function. Some observational studies have linked vitamin E deficiency to increased capillary fragility, but supplementation in otherwise healthy individuals has not consistently demonstrated significant benefits for capillary health. Major systematic reviews and clinical guidelines do not recommend vitamin E solely for capillary support due to insufficient evidence.

Overall, while there is some biological plausibility and weak clinical evidence supporting vitamin E’s role in capillary integrity, the use is not strongly validated by high-quality human research. Therefore, the evidence rating is a 2 out of 5.

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