Vitamin E, encompassing both tocopherols and tocotrienols, has been investigated for its effects on vascular health, including the capillaries. Scientific studies indicate that Vitamin E acts as a potent lipid-soluble antioxidant, protecting cell membranes from oxidative damage. Oxidative stress is a key factor in endothelial dysfunction, which can contribute to capillary fragility and increased permeability. Some in vitro and animal studies suggest that Vitamin E may help stabilize capillary walls by reducing oxidative injury and inflammation. There is also limited evidence from small human studies indicating that Vitamin E supplementation might improve microcirculatory function and reduce capillary permeability in specific populations, such as individuals with diabetes or chronic venous insufficiency.

However, the overall quality and quantity of clinical evidence directly supporting the use of Vitamin E specifically for capillary health in the general population remain limited. Most research has focused on broader cardiovascular outcomes rather than targeted capillary support. Results from large-scale clinical trials on cardiovascular endpoints have been mixed, and benefits do not consistently extend to capillary-specific measures. Therefore, while there is a plausible scientific rationale and some supportive early evidence, robust clinical validation is lacking, and further research is needed to confirm the efficacy of Vitamin E for direct capillary support.