Evidence supporting the use of: Vitamin E (mixed tocopherols/tocotrienols)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, which includes mixed tocopherols and tocotrienols, is an antioxidant nutrient often discussed in relation to vascular health, including the integrity of capillaries. Scientific evidence shows that Vitamin E protects cell membranes from oxidative damage, which theoretically could help maintain capillary strength and function. Some studies have demonstrated that Vitamin E supplementation can reduce oxidative stress in endothelial cells, the cells lining the capillaries and blood vessels. There is also evidence from animal and limited human studies that Vitamin E deficiency can increase capillary fragility, suggesting a role in maintaining capillary integrity. For example, classic symptoms of Vitamin E deficiency include hemolytic anemia and increased capillary permeability.

However, robust clinical trials specifically evaluating Vitamin E supplementation for the purpose of improving capillary health in otherwise healthy humans are lacking. Most human research has focused on cardiovascular outcomes such as atherosclerosis or peripheral vascular disease, not specifically on capillary function. Epidemiological data suggest that adequate Vitamin E status is associated with better vascular health generally, but direct evidence for capillary support is limited. Thus, while there is scientific rationale and some supportive data, the overall evidence is modest and does not strongly support routine use of Vitamin E supplements solely to support capillary health.

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