Evidence supporting the use of: Vitamin E (mixed tocotrienols)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E, particularly in the form of mixed tocotrienols and tocopherols, has scientific validation for supporting capillary health, though the evidence is moderate. Vitamin E acts as a lipid-soluble antioxidant, protecting cell membranes—including those of endothelial cells lining capillaries—from oxidative stress and free radical damage. Several in vitro and animal studies have demonstrated that tocotrienols can help reduce endothelial dysfunction by lowering oxidative stress, inflammation, and improving nitric oxide bioavailability, all of which are important for the maintenance of healthy capillaries and microvascular function.

Some human studies indicate that Vitamin E supplementation may improve microcirculation, particularly in populations with increased oxidative stress such as diabetics or individuals with cardiovascular disease. For example, research published in journals such as Atherosclerosis and the Journal of Nutrition has reported that tocotrienols can reduce markers of endothelial inflammation and improve vascular reactivity.

However, while the antioxidant and anti-inflammatory roles of Vitamin E are well-established, direct clinical evidence specifically showing that mixed tocotrienols improve capillary structure or function in healthy people is limited. Most data are extrapolated from broader cardiovascular or endothelial studies. Therefore, while there is a scientific rationale and some supporting evidence, the strength of clinical evidence specifically for capillary support is moderate rather than robust.

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