Vitamin E, encompassing both tocopherols and tocotrienols, is widely recognized for its antioxidant properties. Its proposed role in supporting the capillary system (small blood vessels) is based on its capacity to protect cell membranes from oxidative damage, which could, in theory, help maintain vascular integrity. Some scientific studies have explored the benefits of Vitamin E on endothelial function and microcirculation, especially in conditions associated with oxidative stress, such as diabetes and hypertension. There is limited evidence suggesting that Vitamin E supplementation may improve capillary fragility and reduce leakage in certain populations, such as individuals with chronic venous insufficiency or those prone to easy bruising. However, most of the evidence stems from small clinical trials or animal studies, and results are often inconsistent.

Systematic reviews and larger randomized controlled trials have yielded mixed findings regarding Vitamin E's effectiveness in vascular health. Furthermore, while Vitamin E deficiency can impair vascular function, supplementation in individuals with normal Vitamin E status does not consistently translate to measurable improvements in capillary health. As a result, while there is a plausible scientific rationale and some supporting data, the overall evidence base is modest and does not firmly establish Vitamin E as a primary intervention for capillary support.