Evidence supporting the use of: Xantinol Nicotinate
For the body system: Capillaries
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Xantinol nicotinate is a vasodilator compound formed from xanthinol and nicotinic acid (niacin). It has been used in clinical settings, particularly in Europe, to improve peripheral and cerebral blood flow. The rationale behind its use to support the capillary system is primarily its pharmacological action as a vasodilator, where it promotes blood flow through the dilation of small blood vessels, including capillaries. Several studies have investigated its effects in conditions involving impaired microcirculation, such as peripheral vascular disease and cerebrovascular insufficiency. The evidence base consists mainly of older clinical trials and publications, many of which report improved microcirculatory parameters and symptomatic relief in patients with vascular disorders. However, high-quality, large-scale randomized controlled trials are limited, and most studies are dated, with few conducted according to modern clinical research standards. There is some support for improved blood flow and capillary function, but the overall strength of the evidence is moderate at best, and it is not widely used in contemporary practice outside specific regions. In summary, there is scientific—though not robust—evidence supporting xantinol nicotinate’s use for capillary and microcirculatory support, meriting a mid-level rating for efficacy.
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