Evidence supporting the use of: Diosmin
For the health condition: Capillary Weakness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Diosmin is a flavonoid compound derived mainly from citrus fruits and is widely used in Europe as a venoactive drug. Its use for supporting or treating capillary weakness, also referred to as capillary fragility, is primarily supported by scientific evidence. Multiple clinical studies, systematic reviews, and meta-analyses have indicated that diosmin, often used in combination with hesperidin, improves microcirculation and strengthens capillary resistance. The mechanism behind diosmin’s effects includes its ability to reduce capillary permeability, enhance venous tone, and improve lymphatic drainage. These actions contribute to a reduction in symptoms such as edema, bruising, and microvascular leakage, which are indicative of capillary weakness. A pivotal review published in Phytotherapy Research (2012) and a meta-analysis in International Angiology (2015) both concluded that diosmin significantly reduces capillary permeability and increases capillary resistance in patients with chronic venous insufficiency (CVI) and related microvascular disorders. These findings are supported by randomized controlled trials showing objective improvements in capillary fragility tests and subjective improvement in symptoms like bruising and swelling. Although more large-scale, high-quality studies would help further solidify these findings, current evidence justifies diosmin’s use in managing capillary weakness, with a favorable safety profile and a long history of use in European pharmacopoeias.

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