Evidence supporting the use of: Hesperidin methyl chalcone
For the health condition: Capillary Weakness

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperidin methyl chalcone is a semi-synthetic derivative of hesperidin, a bioflavonoid commonly found in citrus fruits. Its use in supporting or treating capillary weakness is primarily based on scientific evidence, particularly from studies and clinical trials conducted in Europe. Hesperidin methyl chalcone is known for its vasoprotective properties, which include strengthening capillary walls, reducing capillary permeability, and improving venous tone. These effects are believed to be due to its ability to modulate inflammatory mediators, stabilize collagen and elastin fibers in blood vessels, and exhibit antioxidant activity.

Clinical studies, especially in the context of chronic venous insufficiency, hemorrhoids, and capillary fragility (such as that seen in purpura or easy bruising), have shown that hesperidin methyl chalcone can decrease symptoms like edema, heaviness, and spontaneous bruising. In several randomized controlled trials, patients receiving hesperidin methyl chalcone, often in combination with other flavonoids (like diosmin), demonstrated improved capillary resistance and reduced permeability compared to placebo. Regulatory agencies in some European countries recognize hesperidin methyl chalcone as an approved ingredient for venous and capillary disorders. However, while the evidence is fairly strong, it is not universally conclusive due to variations in study design, sample sizes, and combination with other ingredients.

In summary, hesperidin methyl chalcone is supported by moderate scientific evidence for use in capillary weakness, with a well-established safety profile and a mechanism of action consistent with clinical benefits observed in studies.

More about Hesperidin methyl chalcone
More about Capillary Weakness

Other health conditions supported by Hesperidin methyl chalcone

Capillary Weakness
Circulation (poor)
Edema
Hemorrhoids
Phlebitis
Spider Veins
Varicose Veins

Products containing Hesperidin methyl chalcone

We currently have no products on Vitabase that contain this ingredient.