Quisqualis indica, also known as Rangoon Creeper, has been traditionally used in various systems of folk medicine, particularly in Asia, for a range of conditions including parasitic infections, skin disorders, and inflammation. In the context of carbuncles—a type of deep skin abscess—the use of Quisqualis is primarily rooted in traditional practices. Texts in traditional Chinese medicine and some Ayurvedic sources mention its application for skin eruptions, boils, and related conditions, often as part of a polyherbal preparation rather than as a single agent. Literature suggests that Quisqualis may have mild antimicrobial and anti-inflammatory properties, which could theoretically provide some benefit for infections such as carbuncles.

However, scientific validation for its efficacy in treating carbuncles is minimal. Few pharmacological studies have examined Quisqualis for direct antibacterial activity relevant to the pathogens commonly responsible for carbuncles (e.g., Staphylococcus aureus). The research that does exist is preliminary, often conducted in vitro, and not specific to carbuncles. There are no controlled clinical trials in humans supporting the use of Quisqualis for this indication. Thus, while its use is supported by tradition, the evidence base is weak and primarily anecdotal.