Evidence supporting the use of: Catecholamine
For the health condition: Cardiac Arrest

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Catecholamines, such as epinephrine and norepinephrine, are well-established agents in the treatment of cardiac arrest, particularly in advanced cardiac life support (ACLS) protocols. Their use is supported by robust scientific evidence and is recommended in major guidelines, including those from the American Heart Association (AHA) and European Resuscitation Council (ERC). Epinephrine is the primary catecholamine used during cardiac arrest, administered to increase coronary and cerebral perfusion pressures during cardiopulmonary resuscitation (CPR) through its alpha-adrenergic vasoconstrictive effects. This action helps restore spontaneous circulation by improving blood flow to vital organs when cardiac output is absent or severely compromised.

Numerous randomized controlled trials and meta-analyses have examined epinephrine's role in cardiac arrest. While epinephrine has been consistently shown to increase the rate of return of spontaneous circulation (ROSC), its impact on long-term survival and neurological outcomes is more nuanced, with some studies suggesting only modest benefits. Nevertheless, the consensus remains that its immediate life-saving effects justify its use. Norepinephrine is less commonly used acutely in cardiac arrest but may be considered for post-resuscitation shock. In summary, the use of catecholamines in cardiac arrest is grounded in extensive scientific validation and is a mainstay of modern resuscitation practices.

More about Catecholamine
More about Cardiac Arrest

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