Evidence supporting the use of: Inositol nicotinate
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Inositol nicotinate, also known as inositol hexanicotinate or "no-flush niacin," has been traditionally used as a supplement to support cardiovascular health, primarily due to its relationship with niacin (vitamin B3). Niacin itself has a long history of use in managing cholesterol levels, specifically for lowering LDL cholesterol and raising HDL cholesterol, which are relevant to cardiovascular disease risk. Inositol nicotinate was developed to provide a form of niacin that avoids the common side effect of skin flushing associated with standard niacin therapy.

However, scientific evidence supporting inositol nicotinate’s effectiveness for cardiovascular disease is limited. Some small and older studies suggest that it may have modest lipid-lowering effects, but these effects are not as well established or as potent as those seen with pharmacological doses of standard niacin. Additionally, more recent evidence suggests that inositol nicotinate does not reliably lower cholesterol or improve other cardiovascular risk factors compared to regular niacin. Major clinical guidelines do not recommend its use for cardiovascular disease, and regulatory agencies in some countries have restricted its use due to lack of proven benefit.

In summary, the use of inositol nicotinate for cardiovascular disease is based more on tradition and its association with niacin than on robust scientific evidence. It is not considered an evidence-based therapy for this indication.

More about inositol nicotinate
More about Cardiovascular Disease

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Products containing inositol nicotinate

We currently have no products on Vitabase that contain this ingredient.