Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine, a non-essential amino acid, has attracted some scientific interest for its potential role in cardiovascular health. Several preclinical and limited clinical studies suggest that glycine may exert beneficial effects on the cardiovascular system. Glycine is known to function as an inhibitory neurotransmitter and may possess anti-inflammatory, cytoprotective, and anti-platelet aggregation properties. Animal studies have shown that glycine supplementation can reduce oxidative stress, lower blood pressure, and attenuate cardiac remodeling in models of hypertension and heart failure. Mechanistically, glycine may modulate endothelial function, improve nitric oxide bioavailability, and inhibit advanced glycation end product (AGE) formation, all of which are relevant to cardiovascular disease pathogenesis.

Human evidence, however, remains limited. Some observational studies have found inverse associations between plasma glycine levels and markers of cardiovascular risk, such as hypertension and myocardial infarction. A small number of clinical trials have reported that glycine supplementation can reduce blood pressure or improve metabolic parameters (e.g., in patients with metabolic syndrome), but these studies often have methodological limitations such as small sample size or short duration. Currently, there is insufficient high-quality clinical evidence to support the routine use of L-glycine as a treatment for cardiovascular disease, but emerging mechanistic and early clinical data justify further investigation. Therefore, while the use of L-glycine for cardiovascular support is grounded in scientific inquiry rather than tradition, its therapeutic role is not yet firmly established.

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